Ordered assemblies of Fe 3 O 4 and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects

Thi Thuy Duong Pham, Young Hun Seo, Dabin Lee, Juran Noh, Jeongwan Chae, Eunah Kang, Jae Hong Park, Tae Joo Shin, Sehoon Kim, Juhyun Park

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe 3 O 4 ) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe 3 O 4 ) exhibited the shortest transversal relaxation time, T 2 , and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalPolymer
Volume161
DOIs
Publication statusPublished - 2019 Jan 14

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea grants funded by the Korean government (NRF-2016R1D1A1A02937538, 2017M2A2A6A01021427, and 2017M3A9D8029942) and by JSPS KAKENHI (Grant Number 17H06791). Experiments on the PLS-II 6D beamlines were supported in part by MSIT, POSTECH, and UNIST Central Research Facilities. JP acknowledges Profs. Tsunehiro Tanaka and Kentaro Teramura for access to a UV–vis spectrometer and Dr. Yasunari Tamai and Mr. Yasuhiro Murata for their assistance on fs-TA measurements. SK thanks Korea Research Institute of Standards and Science (KRISS-2018-GP2018-0018) for KIST intramural program.

Funding Information:
This work was supported by National Research Foundation of Korea grants funded by the Korean government ( NRF-2016R1D1A1A02937538 , 2017M2A2A6A01021427 , and 2017M3A9D8029942 ) and by JSPS KAKENHI (Grant Number 17H06791 ). Experiments on the PLS-II 6D beamlines were supported in part by MSIT , POSTECH , and UNIST Central Research Facilities. JP acknowledges Profs. Tsunehiro Tanaka and Kentaro Teramura for access to a UV–vis spectrometer and Dr. Yasunari Tamai and Mr. Yasuhiro Murata for their assistance on fs-TA measurements. SK thanks Korea Research Institute of Standards and Science ( KRISS-2018-GP2018-0018 ) for KIST intramural program.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Conjugated polymers
  • Hybrid nanoparticles
  • Iron oxides
  • Magnetic resonance imaging
  • Photoacoustic imaging

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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