Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors

Hye Seung Chung, Jae Gon Kim, Jae Won Kim, Hyung Wook Kim, Bong June Yoon

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Orexin plays diverse roles in regulating behaviors, such as sleep and wake, reward processing, arousal, and stress and anxiety. The orexin system may accomplish these multiple tasks through its complex innervations throughout the brain. The emerging evidence indicates a role of orexin in emotional behaviors; however, most of the previous studies have investigated the function of orexin in naïve animals. Here, we examined a functional role of orexin in mice that had been exposed to repeated stress. Chronic social defeat stress produced differential social interaction behaviors in mice (susceptible versus resilient) and these two groups of mice displayed different levels of prepro-orexin in the hypothalamus. Exogenously added orexin A to the brain induced an antidepressant-like effect in only the susceptible mice but not in the resilient mice. In contrast, orexin A and orexin B infused together produced an anxiogenic effect in only the resilient mice and not in the susceptible mice. Furthermore, we found that the antidepressant-like effect of orexin A is mediated by the bed nucleus of the stria terminalis (BNST) after exposure to chronic restraint stress. These findings reveal a bimodal effect of the orexin system in regulating emotional behavior that depends on stress susceptibility.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalRegulatory Peptides
Publication statusPublished - 2014 Nov 1

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) and was funded by the Ministry of Education, Science, and Technology ( NRF-2009-0075797 ).

Publisher Copyright:
© 2014 Elsevier B.V.


  • Anxiety
  • Orexin
  • Social defeat stress
  • Stress susceptibility

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


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