Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Yun Hak Lee; Nayoung Park; Young Bin Park; Yu Jeong Hwang; Chulhun Kang; Jong Seung Kim

doi:10.1039/c4cc00091a

Organelle-selective fluorescent Cu²⁺ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Yun Hak Lee, Nayoung Park, Young Bin Park, Yu Jeong Hwang, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

Two novel Cu²⁺ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu²⁺ sensing. The ER-selective Cu²⁺ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.

Original language	English
Pages (from-to)	3197-3200
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	24
DOIs	https://doi.org/10.1039/c4cc00091a
Publication status	Published - 2014 Feb 25

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c4cc00091a

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abstract = "Two novel Cu2+ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu2+ sensing. The ER-selective Cu2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.",

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AU - Hwang, Yu Jeong

AU - Kang, Chulhun

AU - Kim, Jong Seung

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AB - Two novel Cu2+ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu2+ sensing. The ER-selective Cu2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.

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Organelle-selective fluorescent Cu²⁺ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Abstract

ASJC Scopus subject areas

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