Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Yun Hak Lee; Nayoung Park; Young Bin Park; Yu Jeong Hwang; Chulhun Kang; Jong Seung Kim

doi:10.1039/c4cc00091a

Organelle-selective fluorescent Cu²⁺ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Yun Hak Lee, Nayoung Park, Young Bin Park, Yu Jeong Hwang, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Two novel Cu²⁺ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu²⁺ sensing. The ER-selective Cu²⁺ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.

Original language	English
Pages (from-to)	3197-3200
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	24
DOIs	https://doi.org/10.1039/c4cc00091a
Publication status	Published - 2014 Feb 25

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c4cc00091a

Cite this

@article{d653d7bbd7244049af2a027a6b4c66b6,

title = "Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading",

abstract = "Two novel Cu2+ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu2+ sensing. The ER-selective Cu2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.",

author = "Lee, {Yun Hak} and Nayoung Park and Park, {Young Bin} and Hwang, {Yu Jeong} and Chulhun Kang and Kim, {Jong Seung}",

year = "2014",

month = feb,

day = "25",

doi = "10.1039/c4cc00091a",

language = "English",

volume = "50",

pages = "3197--3200",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "24",

}

TY - JOUR

T1 - Organelle-selective fluorescent Cu2+ ion probes

T2 - revealing the endoplasmic reticulum as a reservoir for Cu-overloading

AU - Lee, Yun Hak

AU - Park, Nayoung

AU - Park, Young Bin

AU - Hwang, Yu Jeong

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2014/2/25

Y1 - 2014/2/25

N2 - Two novel Cu2+ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu2+ sensing. The ER-selective Cu2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.

AB - Two novel Cu2+ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu2+ sensing. The ER-selective Cu2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.

UR - http://www.scopus.com/inward/record.url?scp=84896884935&partnerID=8YFLogxK

U2 - 10.1039/c4cc00091a

DO - 10.1039/c4cc00091a

M3 - Article

C2 - 24519529

AN - SCOPUS:84896884935

SN - 1359-7345

VL - 50

SP - 3197

EP - 3200

JO - Chemical Communications

JF - Chemical Communications

IS - 24

ER -

Organelle-selective fluorescent Cu²⁺ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this