Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Yun Hak Lee, Nayoung Park, Young Bin Park, Yu Jeong Hwang, Chulhun Kang, Jong Seung Kim

    Research output: Contribution to journalArticlepeer-review

    105 Citations (Scopus)

    Abstract

    Two novel Cu2+ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu2+ sensing. The ER-selective Cu2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.

    Original languageEnglish
    Pages (from-to)3197-3200
    Number of pages4
    JournalChemical Communications
    Volume50
    Issue number24
    DOIs
    Publication statusPublished - 2014 Feb 25

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Catalysis
    • Ceramics and Composites
    • General Chemistry
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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