Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy

Sehoon Kim; Tymish Y. Ohulchanskyy; Dhruba Bharali; Yihui Chen; Ravindra K. Pandey; Paras N. Prasad

doi:10.1021/jp900573s

Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy

Sehoon Kim
, Tymish Y. Ohulchanskyy
, Dhruba Bharali
, Yihui Chen
, Ravindra K. Pandey
, Paras N. Prasad

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

We report a novel nanoassembly formulation for photodynamic therapy, which is composed of covalently iodine-concentrated organically modified silica (ORMOSIL) nanoparticles (diameter < 30 nm) and a hydrophobic photosensitizer embedded therein. Comparative studies with iodinated and noniodinated nanoparticles have demonstrated that the intraparticle external heavy-atom effect on the encapsulated photosensitizer molecules significantly enhances the efficiency of ¹O ₂ generation and, thereby, the in vitro PDT efficacy.

Original language	English
Pages (from-to)	12641-12644
Number of pages	4
Journal	Journal of Physical Chemistry C
Volume	113
Issue number	29
DOIs	https://doi.org/10.1021/jp900573s
Publication status	Published - 2009 Jul 23
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

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10.1021/jp900573s

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Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy. / Kim, Sehoon; Ohulchanskyy, Tymish Y.; Bharali, Dhruba et al.
In: Journal of Physical Chemistry C, Vol. 113, No. 29, 23.07.2009, p. 12641-12644.

Research output: Contribution to journal › Article › peer-review

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abstract = "We report a novel nanoassembly formulation for photodynamic therapy, which is composed of covalently iodine-concentrated organically modified silica (ORMOSIL) nanoparticles (diameter < 30 nm) and a hydrophobic photosensitizer embedded therein. Comparative studies with iodinated and noniodinated nanoparticles have demonstrated that the intraparticle external heavy-atom effect on the encapsulated photosensitizer molecules significantly enhances the efficiency of 1O 2 generation and, thereby, the in vitro PDT efficacy.",

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AU - Chen, Yihui

AU - Pandey, Ravindra K.

AU - Prasad, Paras N.

PY - 2009/7/23

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AB - We report a novel nanoassembly formulation for photodynamic therapy, which is composed of covalently iodine-concentrated organically modified silica (ORMOSIL) nanoparticles (diameter < 30 nm) and a hydrophobic photosensitizer embedded therein. Comparative studies with iodinated and noniodinated nanoparticles have demonstrated that the intraparticle external heavy-atom effect on the encapsulated photosensitizer molecules significantly enhances the efficiency of 1O 2 generation and, thereby, the in vitro PDT efficacy.

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ER -

Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy

Abstract

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