Abstract
Objective: To report a case of oxaliplatin-combined chemotherapy-induced interstitial lung disease. Clinical Presentation and Intervention: A 57-year-old man was referred complaining of dyspnea and fever after treatment with an oxaliplatin-combined chemotherapeutic agent for metastatic colorectal cancer. Fever development and spontaneous subsidence were observed during the chemotherapeutic course repeatedly until the 9th cycle. A computer-tomographic (CT) scan revealed bilateral, peripherally distributed, patchy consolidation suggestive of an interstitial lung disease. As a confirmative step, video-assisted thoracoscopic surgical biopsy was attempted; the characteristic intraluminal organizing fibrous plug in the bronchioles and alveoli was seen. Corticosteroid therapy was administered, which rapidly improved the patient's symptoms and chest CT findings. Conclusion: This case showed that oxaliplatin may be implicated in the etiology of interstitial lung disease, since withdrawal of the drug resulted in improvement of interstitial lung disease.
| Original language | English |
|---|---|
| Pages (from-to) | 89-92 |
| Number of pages | 4 |
| Journal | Medical Principles and Practice |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Dec |
| Externally published | Yes |
Keywords
- Interstitial pneumonia
- Organizing pneumonia
- Oxaliplatin
- Pulmonary toxicity
ASJC Scopus subject areas
- Medicine(all)
