Organocatalytic asymmetric michael addition of ketones to α, β-unsaturated nitro compounds

Jae Ho Shim, Si Hun Nam, Byeong Seon Kim, Deok Chan Ha

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


An organic catalyst “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative” was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst in neutral condition provides high chemical yield and enantioselectivities (ee) (up to 96% yield, 98% ee).

Original languageEnglish
Article number618
Issue number6
Publication statusPublished - 2020 Jun

Bibliographical note

Funding Information:
Funding: This work was support by National Research Foundation of Korea (NRF) grant funded by the Korean government [NRF-2019R1814112], [NRF-2020R1C1C1013785].

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Asymmetric
  • Enantioselectivity
  • Organocatalyst
  • Thiourea catalyst
  • Yield

ASJC Scopus subject areas

  • Environmental Science(all)
  • Catalysis
  • Physical and Theoretical Chemistry


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