An organic catalyst “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative” was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst in neutral condition provides high chemical yield and enantioselectivities (ee) (up to 96% yield, 98% ee).
Bibliographical noteFunding Information:
Funding: This work was support by National Research Foundation of Korea (NRF) grant funded by the Korean government [NRF-2019R1814112], [NRF-2020R1C1C1013785].
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Thiourea catalyst
ASJC Scopus subject areas
- Environmental Science(all)
- Physical and Theoretical Chemistry