Orthogonality and compatibility between Tsc and Fmoc amino-protecting groups

Jin Seok Choi, Hunhui Kang, Nakcheol Jeong, Hogyu Han

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


New deprotection conditions that provide a complete orthogonality between Tsc and Fmoc amino-protecting groups are described. The potential of these orthogonal deprotection conditions was then demonstrated by the efficient solid-phase synthesis of branched peptides 20 and 21 using doubly protected amino acids such as Tsc-Lys(Fmoc)-OH 4c and Fmoc-Lys(Tsc)-OH 4d.

Original languageEnglish
Pages (from-to)2493-2503
Number of pages11
Issue number9
Publication statusPublished - 2005 Feb 28

Bibliographical note

Funding Information:
This work was financially supported by the Korea Research Foundation Grant (KRF-2003-015-C00377). Fellowship support from the BK21 and CRM programs (J.S.C. and H.K.) is gratefully acknowledged.


  • Amino-protecting group
  • Branched peptide
  • Fmoc
  • Orthogonal deprotection
  • Tsc

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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