Osmotic deformability of erythrocytes at various shear stresses

Yujin Heo, Hyunwoo Jung, Sehyun Shin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Red blood cell (RBC) deformability is greatly affected by the osmolality, and maximum deformability, which is determined as maximal elongation index (EI<inf>max</inf>), is usually observed in isotonic conditions at high shear stresses (>20 Pa). Therefore, we examined osmotic RBC deformability over a range of shear stresses (0.5-20 Pa). We found that the RBC deformability at low shear stresses (1-3 Pa) was maximum in hypotonic conditions (225-250 mOsm/kg H<inf>2</inf>O), which is slightly lower than the normal range of osmolality in plasma (290-310 mOsm/kg H<inf>2</inf>O). The phenomenon that O<inf>max</inf> (the osmolality at EI<inf>max</inf>) is dependent on applied shear stress could play an important role in microcirculation in which osmolality varies widely.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalClinical Hemorheology and Microcirculation
Issue number3
Publication statusPublished - 2015


  • deformability
  • in vivo
  • osmolality
  • RBC
  • shear stress

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine


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