Osteoporosis in patients with asthma–chronic obstructive pulmonary disease overlap syndrome

Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Sung Yong Lee, Jae Jeong Shim, Kyung Ho Kang, Gyu Young Hur

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)


    Background: Osteoporosis is a common disease that occurs comorbidly in patients with chronic inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap syndrome (ACOS). However, the prevalence of osteoporosis in patients with ACOS has not widely been evaluated. Therefore, we investigated the prevalence of osteoporosis and its relationship with the clinical parameters of patients with asthma, COPD, and ACOS. Methods: This was a retrospective, cross-sectional study. Bone mineral density (BMD), lung function tests, and disease status evaluations were conducted. Results: A total of 321 patients were enrolled: 138 with asthma, 46 with ACOS, and 137 with COPD. One hundred and ninety-three patients (60.1%) were diagnosed with osteoporosis (53.6% of asthma, 65.2% of ACOS, and 65.0% of COPD). Patients with ACOS showed a significantly lower BMD and T-score than did those with asthma. In addition to age, sex, and body mass index (BMI), which were previously reported to be associated with BMD, BMD also had a negative correlation with the diagnosis of ACOS, as compared to a diagnosis of asthma, after adjusting for age, sex, BMI, smoking, and inhaled corticosteroid use (p=0.001). Among those patients with COPD and ACOS, BMD was negatively associated with the COPD Assessment Test (CAT) after adjustment (p<0.001). Inhaled corticosteroid was not associated with the prevalence of osteoporosis and BMD. Conclusion: Patients with ACOS, particularly aged and lean women, should be more carefully monitored for osteoporosis as compared to patients with asthma.

    Original languageEnglish
    Pages (from-to)73-79
    Number of pages7
    JournalTuberculosis and Respiratory Diseases
    Issue number1
    Publication statusPublished - 2018 Jan


    • Asthma
    • Bone Mineral Density
    • Chronic Obstructive
    • Osteoporosis
    • Pulmonary Disease
    • Syndrome

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Infectious Diseases


    Dive into the research topics of 'Osteoporosis in patients with asthma–chronic obstructive pulmonary disease overlap syndrome'. Together they form a unique fingerprint.

    Cite this