Overexpression of neurogenin induces ectopic expression of HuC in zebrafish

Cheol Hee Kim, Young Ki Bae, Yojiro Yamanaka, Susumu Yamashita, Takashi Shimizu, Ritsuko Fujii, Hae Chul Park, Sang Yeob Yeo, Tae Lin Huh, Masahiko Hibi, Toshio Hirano

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


Several basic helix-loop-helix (bHLH) transcription factors are known to be involved in vertebrate neurogenesis. To investigate their roles in zebrafish neurogenesis, we isolated cDNAs for homologues of neurogenin and Math-1/atonal. The transcription of neurogenin was first detectable in zebrafish nervous system at late gastrulation stage. The expression of zebrafish neurogenin precedes and overlaps that of HuC, one of the earliest neuronal precursor markers. Injection of neurogenin mRNA into early stage zebrafish embryos induced ectopic expression of HuC. These results suggest that neurogenin may participate in the generation of HuC-expressing cells, implying its role in neuronal determination in zebrafish.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalNeuroscience Letters
Issue number2-3
Publication statusPublished - 1997 Dec 15
Externally publishedYes


  • HuC
  • Neural plate
  • Neurogenin
  • Neuronal determination
  • ZATH-1
  • Zebrafish

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Overexpression of neurogenin induces ectopic expression of HuC in zebrafish'. Together they form a unique fingerprint.

Cite this