TY - JOUR
T1 - Overexpression of PD-L2 is associated with shorter relapse-free survival in patients with malignant salivary gland tumors
AU - Chang, Hyeyoon
AU - Kim, Jung Sun
AU - Choi, Yoon Ji
AU - Cho, Jae Gu
AU - Woo, Jeong Soo
AU - Kim, Aeree
AU - Kim, Jun Suk
AU - Kang, Eun Joo
N1 - Funding Information:
The biospecimens for this study were provided by the Korea University Guro Hospital of National Biobank, a member of the National Biobank of Korea. The study was supported by a grant received by Dr Eun Joo Kang from Korea University, Seoul, Korea (K1422231).
Publisher Copyright:
© 2017 Chang et al.
PY - 2017/6/13
Y1 - 2017/6/13
N2 - Objectives: PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an important role in tumor evasion. This study aimed to investigate expression patterns of immune-related molecules, and their clinical impacts in malignant salivary gland tumors. Patients and methods: We performed immunohistochemical staining for PD-L1, PD-L2, CTLA-4, PD-1, and CD8+ tumor-infiltrating lymphocytes in 70 malignant salivary gland tumors. Protein expression was assessed by H-score by multiplying the staining intensity by the percentage of cells with positive staining. Results: The tumors comprised mucoepidermoid carcinomas (38.6%), adenoid cystic carcinomas (21.4%), salivary duct carcinomas (15.7%), and others. In malignant salivary gland tumors, PD-L2 expression was high, while expression of PD-L1 was relatively low in terms of the percentage of positively stained cells and the staining intensity. In univariate analysis, PD-L2 expression (H-score,1 vs ≥1), PD-1 (H-score,1 vs ≥1), and CD8+ tumor-infiltrating lymphocytes (H-score,1 vs ≥1) were significant prognostic factors. In multivariate analysis, low PD-L2 expression (H-score,1) was independently associated with shorter relapse-free survival (hazard ratio =6.514; 95% confidence interval, 1.2-36.2; P=0.032). Conclusion: In summary, PD-L2 is potentially an important biomarker in malignant salivary gland tumors, especially in regard to relapse.
AB - Objectives: PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an important role in tumor evasion. This study aimed to investigate expression patterns of immune-related molecules, and their clinical impacts in malignant salivary gland tumors. Patients and methods: We performed immunohistochemical staining for PD-L1, PD-L2, CTLA-4, PD-1, and CD8+ tumor-infiltrating lymphocytes in 70 malignant salivary gland tumors. Protein expression was assessed by H-score by multiplying the staining intensity by the percentage of cells with positive staining. Results: The tumors comprised mucoepidermoid carcinomas (38.6%), adenoid cystic carcinomas (21.4%), salivary duct carcinomas (15.7%), and others. In malignant salivary gland tumors, PD-L2 expression was high, while expression of PD-L1 was relatively low in terms of the percentage of positively stained cells and the staining intensity. In univariate analysis, PD-L2 expression (H-score,1 vs ≥1), PD-1 (H-score,1 vs ≥1), and CD8+ tumor-infiltrating lymphocytes (H-score,1 vs ≥1) were significant prognostic factors. In multivariate analysis, low PD-L2 expression (H-score,1) was independently associated with shorter relapse-free survival (hazard ratio =6.514; 95% confidence interval, 1.2-36.2; P=0.032). Conclusion: In summary, PD-L2 is potentially an important biomarker in malignant salivary gland tumors, especially in regard to relapse.
KW - CTLA-4
KW - Malignant salivary gland tumors
KW - PD-L1
KW - PD-L2
KW - Relapse-free survival
KW - Tumor-infiltrating lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=85020850390&partnerID=8YFLogxK
U2 - 10.2147/OTT.S134589
DO - 10.2147/OTT.S134589
M3 - Article
AN - SCOPUS:85020850390
SN - 1178-6930
VL - 10
SP - 2983
EP - 2992
JO - OncoTargets and Therapy
JF - OncoTargets and Therapy
ER -