Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease

Hye Ri Park, Jiyoon Kim, Taekeun Kim, Seonmi Jo, Miyoung Yeom, Bongjin Moon, Il Han Choo, Jaeick Lee, Eun Jeong Lim, Ki Duk Park, Sun Joon Min, Ghilsoo Nam, Gyochang Keum, C. Justin Lee, Hyunah Choo

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


In Parkinson's disease, the motor impairments are mainly caused by the death of dopaminergic neurons. Among the enzymes which are involved in the biosynthesis and catabolism of dopamine, monoamine oxidase B (MAO-B) has been a therapeutic target of Parkinson's disease. However, due to the undesirable adverse effects, development of alternative MAO-B inhibitors with greater optimal therapeutic potential towards Parkinson's disease is urgently required. In this study, we designed and synthesized the oxazolopyridine and thiazolopyridine derivatives, and biologically evaluated their inhibitory activities against MAO-B. Structure-activity relationship study revealed that the piperidino group was the best choice for the R1 amino substituent to the oxazolopyridine core structure and the activities of the oxazolopyridines with various phenyl rings were between 267.1 and 889.5 nM in IC50 values. Interestingly, by replacement of the core structure from oxazolopyrine to thiazolopyridine, the activities were significantly improved and the compound 1n with the thiazolopyridine core structure showed the most potent activity with the IC50 value of 26.5 nM. Molecular docking study showed that van der Waals interaction in the human MAO-B active site could explain the enhanced inhibitory activities of thiazolopyridine derivatives.

Original languageEnglish
Pages (from-to)5480-5487
Number of pages8
JournalBioorganic and Medicinal Chemistry
Issue number17
Publication statusPublished - 2013 Sept 1


  • MAO-B
  • Monoamine oxidase B
  • Oxazolopyridine
  • Parkinson's disease
  • Thiazolopyridine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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