Oxidative Stress and Antioxidants in Chronic Rhinosinusitis with Nasal Polyps

Junhu Tai, Jae Min Shin, Jaehyung Park, Munsoo Han, Tae Hoon Kim

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Oxidative stress results from an imbalance between the production of reactive oxygen species and the body’s antioxidant defense system. It plays an important role in the regulation of the immune response and can be a pathogenic factor in various diseases. Chronic rhinosinusitis (CRS) is a complex and heterogeneous disease with various phenotypes and endotypes. Recently, an increasing number of studies have proposed that oxidative stress (caused by both environmental and intrinsic stimuli) plays an important role in the pathogenesis and persistence of CRS. This has attracted the attention of several researchers. The relationship between the presence of reactive oxygen species composed of free radicals and nasal polyp pathology is a key topic receiving attention. This article reviews the role of oxidative stress in respiratory diseases, particularly CRS, and introduces potential therapeutic antioxidants that may offer targeted treatment for CRS.

Original languageEnglish
Article number195
JournalAntioxidants
Volume12
Issue number1
DOIs
Publication statusPublished - 2023 Jan

Bibliographical note

Funding Information:
This research was funded by the Basic Science Research Program of the National Research Foundation, the Ministry of Science and Technology, and the Ministry of Science, ICT, and Future Planning of Korea (grant numbers 2017R1A2B2003575 and NRF-2020R1A2C1006398). The study was supervised by the Institute for Information and Communications Technology Planning and Evaluation and falls under the ICT Creative Consilience program (IITP-2023-2020-0-01819) of the Ministry of Science and ICT, Korea. Our research was further funded by the Korea Health Technology R&D Project (grant numbers HI17C0387 and HR22C1302) through the Korea Health Industry Development Institute, as administered by the Ministry of Health and Welfare. This research was finally funded by a Korea University grant and a grant from the Korea University Medical Center and Anam Hospital in Seoul, Republic of Korea.

Publisher Copyright:
© 2023 by the authors.

Keywords

  • antioxidants
  • chronic rhinosinusitis
  • mucosa
  • oxidative stress
  • research progress

ASJC Scopus subject areas

  • Food Science
  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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