Abstract
Oxytocin is a mammalian hormone that is released mainly after distension of the uterine cervix. In this study, we report that oxytocin stimulates intracellular release of calcium, and also activates AMPK (AMP-activated protein kinase) in C2C12 myoblast cells in a time/dose-dependent manner. Oxytocin receptor mRNA was detected in C2C12 cells. In addition, oxytocin stimulated glucose uptake and, moreover, inhibition of either CaMKK (Ca2+/calmodulin-dependent protein kinase kinase) or AMPK blocked oxytocin-mediated AMPK activation and glucose uptake. Taken together, our findings suggest that oxytocin may serve a peripheral metabolic function in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
Original language | English |
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Pages (from-to) | 71-74 |
Number of pages | 4 |
Journal | Regulatory Peptides |
Volume | 151 |
Issue number | 1-3 |
DOIs | |
Publication status | Published - 2008 Nov 29 |
Bibliographical note
Funding Information:This study was supported by a grant from Korea University and also supported by Kmep (T28021) to Jong-Soon Choi.
Keywords
- ACC
- AMPK
- CaMKK
- Calcium
- Oxytocin
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Clinical Biochemistry
- Cellular and Molecular Neuroscience