Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway

Eun Soo Lee, Kyung Ok Uhm, Yun Mi Lee, Joseph Kwon, Sun Hwa Park, Kim Hyeon Soo

    Research output: Contribution to journalArticlepeer-review

    58 Citations (Scopus)

    Abstract

    Oxytocin is a mammalian hormone that is released mainly after distension of the uterine cervix. In this study, we report that oxytocin stimulates intracellular release of calcium, and also activates AMPK (AMP-activated protein kinase) in C2C12 myoblast cells in a time/dose-dependent manner. Oxytocin receptor mRNA was detected in C2C12 cells. In addition, oxytocin stimulated glucose uptake and, moreover, inhibition of either CaMKK (Ca2+/calmodulin-dependent protein kinase kinase) or AMPK blocked oxytocin-mediated AMPK activation and glucose uptake. Taken together, our findings suggest that oxytocin may serve a peripheral metabolic function in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.

    Original languageEnglish
    Pages (from-to)71-74
    Number of pages4
    JournalRegulatory Peptides
    Volume151
    Issue number1-3
    DOIs
    Publication statusPublished - 2008 Nov 29

    Bibliographical note

    Funding Information:
    This study was supported by a grant from Korea University and also supported by Kmep (T28021) to Jong-Soon Choi.

    Keywords

    • ACC
    • AMPK
    • CaMKK
    • Calcium
    • Oxytocin

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Endocrinology
    • Clinical Biochemistry
    • Cellular and Molecular Neuroscience

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