Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids

Jinil Hwang, Kyungho Park, Juseok Choe, Hongkeun Min, Kwang Ho Song, Sunwoo Lee

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55 Citations (Scopus)


A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(? 3-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.

Original languageEnglish
Pages (from-to)3267-3271
Number of pages5
JournalJournal of Organic Chemistry
Issue number7
Publication statusPublished - 2014 Apr 4

ASJC Scopus subject areas

  • Organic Chemistry


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