A completely atom economical palladium-catalyzed addition reaction has been developed to stereoselectively access functionalized tetrasubstituted alkenyl iodides. The palladium catalyst, which bears an electron-poor bidentate ligand rarely employed in catalysis, is essential to promote the high yielding and chemoselective intermolecular reaction between equimolar amounts of an alkyne and an aryl iodide. This new carbohalogenation reaction is an attractive alternative to traditional synthetic methods, which rely on multistep synthetic sequences and protecting-group manipulations.
Bibliographical noteFunding Information:
We acknowledge the Max-Planck-Society, the ERC (Shut-tleCat, Project ID: 757608), ETH Zürich and LG Chem (fellowship to Y.H.L.). We thank B. List for sharing analytical equipment, and the NMR, MS and X-ray departments of the MPI für Kohlenforschung for technical assistance.
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- alkenyl iodides
- homogeneous catalysis
ASJC Scopus subject areas
- General Chemistry