Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

Gongcheng Ma, Qihang Ding, Yuding Zhang, Yue Wang, Jingjing Xiang, Mingle Li, Qi Zhao, Saipeng Huang, Ping Gong, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Carbon monoxide (CO) is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties. It plays a pivotal role in a myriad of biological processes. Therefore, the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis. We herein introduce NFCOP, a state-of-the-art near-infrared (NIR) turn-on fluorescence (FL) probe that has been meticulously designed for highly sensitive, swift and selective imaging of CO. The NFCOP response occurred rapidly with CO, within just 10 s, and the calculated detection limit for CO was determined to be 0.32 μmol/L. Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

Original languageEnglish
Article number109293
JournalChinese Chemical Letters
Volume35
Issue number9
DOIs
Publication statusPublished - 2024 Sept

Bibliographical note

Publisher Copyright:
© 2024

Keywords

  • Carbon monoxide
  • Chemoselective probe
  • Fluorescence imaging
  • Near-infrared
  • Palladium-free

ASJC Scopus subject areas

  • General Chemistry

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