Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

Gongcheng Ma; Qihang Ding; Yuding Zhang; Yue Wang; Jingjing Xiang; Mingle Li; Qi Zhao; Saipeng Huang; Ping Gong; Jong Seung Kim

doi:10.1016/j.cclet.2023.109293

Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

Gongcheng Ma, Qihang Ding, Yuding Zhang, Yue Wang, Jingjing Xiang, Mingle Li, Qi Zhao, Saipeng Huang, Ping Gong, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Carbon monoxide (CO) is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties. It plays a pivotal role in a myriad of biological processes. Therefore, the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis. We herein introduce NFCOP, a state-of-the-art near-infrared (NIR) turn-on fluorescence (FL) probe that has been meticulously designed for highly sensitive, swift and selective imaging of CO. The NFCOP response occurred rapidly with CO, within just 10 s, and the calculated detection limit for CO was determined to be 0.32 μmol/L. Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

Original language	English
Article number	109293
Journal	Chinese Chemical Letters
Volume	35
Issue number	9
DOIs	https://doi.org/10.1016/j.cclet.2023.109293
Publication status	Published - 2024 Sept

Bibliographical note

Publisher Copyright:
© 2024

Keywords

Carbon monoxide
Chemoselective probe
Fluorescence imaging
Near-infrared
Palladium-free

ASJC Scopus subject areas

General Chemistry

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10.1016/j.cclet.2023.109293

Cite this

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title = "Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide",

abstract = "Carbon monoxide (CO) is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties. It plays a pivotal role in a myriad of biological processes. Therefore, the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis. We herein introduce NFCOP, a state-of-the-art near-infrared (NIR) turn-on fluorescence (FL) probe that has been meticulously designed for highly sensitive, swift and selective imaging of CO. The NFCOP response occurred rapidly with CO, within just 10 s, and the calculated detection limit for CO was determined to be 0.32 μmol/L. Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.",

keywords = "Carbon monoxide, Chemoselective probe, Fluorescence imaging, Near-infrared, Palladium-free",

author = "Gongcheng Ma and Qihang Ding and Yuding Zhang and Yue Wang and Jingjing Xiang and Mingle Li and Qi Zhao and Saipeng Huang and Ping Gong and Kim, {Jong Seung}",

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doi = "10.1016/j.cclet.2023.109293",

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T1 - Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

AU - Ma, Gongcheng

AU - Ding, Qihang

AU - Zhang, Yuding

AU - Wang, Yue

AU - Xiang, Jingjing

AU - Li, Mingle

AU - Zhao, Qi

AU - Huang, Saipeng

AU - Gong, Ping

AU - Kim, Jong Seung

PY - 2024/9

Y1 - 2024/9

N2 - Carbon monoxide (CO) is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties. It plays a pivotal role in a myriad of biological processes. Therefore, the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis. We herein introduce NFCOP, a state-of-the-art near-infrared (NIR) turn-on fluorescence (FL) probe that has been meticulously designed for highly sensitive, swift and selective imaging of CO. The NFCOP response occurred rapidly with CO, within just 10 s, and the calculated detection limit for CO was determined to be 0.32 μmol/L. Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

AB - Carbon monoxide (CO) is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties. It plays a pivotal role in a myriad of biological processes. Therefore, the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis. We herein introduce NFCOP, a state-of-the-art near-infrared (NIR) turn-on fluorescence (FL) probe that has been meticulously designed for highly sensitive, swift and selective imaging of CO. The NFCOP response occurred rapidly with CO, within just 10 s, and the calculated detection limit for CO was determined to be 0.32 μmol/L. Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

KW - Carbon monoxide

KW - Chemoselective probe

KW - Fluorescence imaging

KW - Near-infrared

KW - Palladium-free

UR - http://www.scopus.com/inward/record.url?scp=85190138072&partnerID=8YFLogxK

U2 - 10.1016/j.cclet.2023.109293

DO - 10.1016/j.cclet.2023.109293

M3 - Article

AN - SCOPUS:85190138072

SN - 1001-8417

VL - 35

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 9

M1 - 109293

ER -

Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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