Panenteritis as an Initial Presentation of Systemic Lupus Erythematosus

Han Ah Lee, Hye Gi Shim, Young Ho Seo, Sung Jae Choi, Beom Jae Lee, Young Ho Lee, Jong Dae Ji, Jae Hoon Kim, Gwan Gyu Song

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Lupus enteritis is a rare, severe complication of systemic lupus erythematosus (SLE), needing prompt diagnosis and proper management. However, SLE rarely presents as lupus enteritis at the time of initial diagnosis. Thus, delayed diagnosis and misdiagnosis are common. We report a case of a 25-year-old woman with lupus panenteritis. The patient had multiple hospitalizations for abdominal pain, nausea, and diarrhea, initially without any other symptoms suggestive of SLE, but was later observed to have malar rash and oral ulcers. Laboratory investigations were compatible with SLE, including positive antinuclear antibody (1:320) with speckled pattern. CT revealed diffuse hypodense submucosal thickening of the stomach, the entire small bowel, colon, appendix, and rectum. Treatment with high-dose corticosteroids followed by maintenance therapy with mycophenolate mofetil, hydroxychloroquine, and azathioprine resulted in clinical improvement. Diagnosis of lupus enteritis requires a high index of suspicion given the low incidence and nonspecific clinical findings.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Issue number2
Publication statusPublished - 2016 Feb 1
Externally publishedYes


  • Enteritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • General Medicine


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