Paradoxical long-term impact of maternal influenza infection on neonates and infants

Joon Young Song, Keon Vin Park, Sung Won Han, Min Joo Choi, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Min Jeong Oh, Geum Joon Cho

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Background: Pregnant women are at high risk of influenza-related morbidity and mortality. In addition, maternal influenza infection may lead to adverse birth outcomes. However, there is insufficient data on long-term impact of maternal influenza infection. Methods: This study was conducted to assess the impact of maternal influenza infection on birth outcomes and long-term influence on infants by merging the Korea National Health Insurance (KNHI) claims database and National Health Screening Program for Infants and Children (NHSP-IC). Mother-offspring pairs were categorized by maternal influenza infection based on the ICD-10 code. Results: Multivariate analysis revealed that maternal influenza infection significantly increased the risk of preterm birth (OR 1.408) and low birth weight (OR 1.198) irrespective of gestational age. The proportion of low birth weight neonates was significantly higher in influenza-infected women compared to those without influenza. However, since the fourth health screening (30-80 months after birth), the fraction of underweight was no longer different between children from influenza-infected and non-infected mothers, whereas the rates of overweight increased paradoxically in those born to mothers with influenza infection. Conclusions: Maternal influenza infection might have long-term effects on the health of children and adolescents even after infancy.

Original languageEnglish
Article number502
JournalBMC infectious diseases
Issue number1
Publication statusPublished - 2020 Jul 11

Bibliographical note

Publisher Copyright:
© 2020 The Author(s).


  • Influenza
  • Low birth weight
  • Obesity
  • Pregnancy
  • Preterm birth

ASJC Scopus subject areas

  • Infectious Diseases


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