Particulate matter (PM)2.5 affects keratinocytes via endoplasmic reticulum (ER) stress-mediated suppression of apoptosis

J. H. Kim; J. W. Son; J. Kim; M. G. Kim; S. H. Jeong; T. J. Park; S. W. Son; H. J. Ryu

doi:10.1007/s13273-019-00065-6

Particulate matter (PM)_2.5 affects keratinocytes via endoplasmic reticulum (ER) stress-mediated suppression of apoptosis

J. H. Kim, J. W. Son, J. Kim, M. G. Kim, S. H. Jeong, T. J. Park, S. W. Son, H. J. Ryu

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: Particulate matter (PM)_2.5 is a concern for public health nowadays. Although few studies have reported the skin diseases associated with PM_2.5, its effects on keratinocytes have yet to be elucidated. Objective: The goal of this experiment was to analyze and identify the changes of gene expression in PM2.5-treated keratinocytes using RNA-sequencing (RNA-Seq) data. Results: PM_2.5-treated keratinocytes exhibited changes in cell cycle-related genes as well as genes involved in DNA replication, endoplasmic reticulum (ER) stress, intrinsic apoptosis, and immune response. A total of 669 genes showed changes in gene expression in PM_2.5-treated keratinocytes, including 304 upregulated and 365 downregulated genes. Conclusion: Unlike other studies investigating skin disorders associated with PM_2.5, our study found the mechanism of apoptosis suppression in keratinocytes. The findings may provide a novel insight into the management of chronic skin diseases in relation to PM_2.5.

Original language	English
Pages (from-to)	129-137
Number of pages	9
Journal	Molecular and Cellular Toxicology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/s13273-019-00065-6
Publication status	Published - 2020 Apr 1

Keywords

Apoptosis
Cell proliferation
Endoplasmic reticulum (ER) stress
Particulate matter (PM)
Psoriasis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology, Toxicology and Pharmaceutics(all)
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s13273-019-00065-6

Cite this

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title = "Particulate matter (PM)2.5 affects keratinocytes via endoplasmic reticulum (ER) stress-mediated suppression of apoptosis",

abstract = "Background: Particulate matter (PM)2.5 is a concern for public health nowadays. Although few studies have reported the skin diseases associated with PM2.5, its effects on keratinocytes have yet to be elucidated. Objective: The goal of this experiment was to analyze and identify the changes of gene expression in PM2.5-treated keratinocytes using RNA-sequencing (RNA-Seq) data. Results: PM2.5-treated keratinocytes exhibited changes in cell cycle-related genes as well as genes involved in DNA replication, endoplasmic reticulum (ER) stress, intrinsic apoptosis, and immune response. A total of 669 genes showed changes in gene expression in PM2.5-treated keratinocytes, including 304 upregulated and 365 downregulated genes. Conclusion: Unlike other studies investigating skin disorders associated with PM2.5, our study found the mechanism of apoptosis suppression in keratinocytes. The findings may provide a novel insight into the management of chronic skin diseases in relation to PM2.5.",

keywords = "Apoptosis, Cell proliferation, Endoplasmic reticulum (ER) stress, Particulate matter (PM), Psoriasis",

author = "Kim, {J. H.} and Son, {J. W.} and J. Kim and Kim, {M. G.} and Jeong, {S. H.} and Park, {T. J.} and Son, {S. W.} and Ryu, {H. J.}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea Grant (NRF), funded by the Korean Government (NRF-2016R1C1B1014180) and Korea University Grants. Funding Information: This work was supported by the National Research Foundation of Korea Grant (NRF), funded by the Korean Government (NRF-2016R1C1B1014180) and Korea University Grants. Publisher Copyright: {\textcopyright} 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.",

year = "2020",

month = apr,

day = "1",

doi = "10.1007/s13273-019-00065-6",

language = "English",

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T1 - Particulate matter (PM)2.5 affects keratinocytes via endoplasmic reticulum (ER) stress-mediated suppression of apoptosis

AU - Kim, J. H.

AU - Son, J. W.

AU - Kim, J.

AU - Kim, M. G.

AU - Jeong, S. H.

AU - Park, T. J.

AU - Son, S. W.

AU - Ryu, H. J.

N1 - Funding Information: This work was supported by the National Research Foundation of Korea Grant (NRF), funded by the Korean Government (NRF-2016R1C1B1014180) and Korea University Grants. Funding Information: This work was supported by the National Research Foundation of Korea Grant (NRF), funded by the Korean Government (NRF-2016R1C1B1014180) and Korea University Grants. Publisher Copyright: © 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Background: Particulate matter (PM)2.5 is a concern for public health nowadays. Although few studies have reported the skin diseases associated with PM2.5, its effects on keratinocytes have yet to be elucidated. Objective: The goal of this experiment was to analyze and identify the changes of gene expression in PM2.5-treated keratinocytes using RNA-sequencing (RNA-Seq) data. Results: PM2.5-treated keratinocytes exhibited changes in cell cycle-related genes as well as genes involved in DNA replication, endoplasmic reticulum (ER) stress, intrinsic apoptosis, and immune response. A total of 669 genes showed changes in gene expression in PM2.5-treated keratinocytes, including 304 upregulated and 365 downregulated genes. Conclusion: Unlike other studies investigating skin disorders associated with PM2.5, our study found the mechanism of apoptosis suppression in keratinocytes. The findings may provide a novel insight into the management of chronic skin diseases in relation to PM2.5.

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