Particulate matter (PM)2.5 affects keratinocytes via endoplasmic reticulum (ER) stress-mediated suppression of apoptosis

J. H. Kim, J. W. Son, J. Kim, M. G. Kim, S. H. Jeong, T. J. Park, S. W. Son, H. J. Ryu

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Background: Particulate matter (PM)2.5 is a concern for public health nowadays. Although few studies have reported the skin diseases associated with PM2.5, its effects on keratinocytes have yet to be elucidated. Objective: The goal of this experiment was to analyze and identify the changes of gene expression in PM2.5-treated keratinocytes using RNA-sequencing (RNA-Seq) data. Results: PM2.5-treated keratinocytes exhibited changes in cell cycle-related genes as well as genes involved in DNA replication, endoplasmic reticulum (ER) stress, intrinsic apoptosis, and immune response. A total of 669 genes showed changes in gene expression in PM2.5-treated keratinocytes, including 304 upregulated and 365 downregulated genes. Conclusion: Unlike other studies investigating skin disorders associated with PM2.5, our study found the mechanism of apoptosis suppression in keratinocytes. The findings may provide a novel insight into the management of chronic skin diseases in relation to PM2.5.

    Original languageEnglish
    Pages (from-to)129-137
    Number of pages9
    JournalMolecular and Cellular Toxicology
    Volume16
    Issue number2
    DOIs
    Publication statusPublished - 2020 Apr 1

    Bibliographical note

    Funding Information:
    This work was supported by the National Research Foundation of Korea Grant (NRF), funded by the Korean Government (NRF-2016R1C1B1014180) and Korea University Grants.

    Funding Information:
    This work was supported by the National Research Foundation of Korea Grant (NRF), funded by the Korean Government (NRF-2016R1C1B1014180) and Korea University Grants.

    Publisher Copyright:
    © 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.

    Keywords

    • Apoptosis
    • Cell proliferation
    • Endoplasmic reticulum (ER) stress
    • Particulate matter (PM)
    • Psoriasis

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Toxicology
    • Pharmacology, Toxicology and Pharmaceutics(all)
    • Public Health, Environmental and Occupational Health
    • Health, Toxicology and Mutagenesis

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