Abstract
The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus.
Original language | English |
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Pages (from-to) | 1135-1140 |
Number of pages | 6 |
Journal | Avian Diseases |
Volume | 47 |
Issue number | SPEC. ISS. |
DOIs | |
Publication status | Published - 2003 |
Externally published | Yes |
Keywords
- Antigenicity
- Avian influenza virus
- Cross-protection
- Pathogenesis
ASJC Scopus subject areas
- Food Animals
- Animal Science and Zoology
- General Immunology and Microbiology