Abstract
High-temperature-requirement A2 (HtrA2)/Omi/PARK13 is a serine protease with extensive homology to the Escherichia coli HtrAs that are required for bacterial survival at high temperatures. The HtrA2 protein is a key modulator of mitochondrial molecular quality control but under stressful conditions it is released into the cytosol, where it promotes cell death by various pathways, including caspase-dependent pathway and ER stress-mediated apoptosis. Recently, the HtrA2 protein has received great attention for its potential role in neurodegeneration. Here, we review the current knowledge and pathophysiological functions of the HtrA2 protein in neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease.
| Original language | English |
|---|---|
| Pages (from-to) | 746-757 |
| Number of pages | 12 |
| Journal | Current Protein and Peptide Science |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 |
Bibliographical note
Funding Information:This study was supported by a grant from the National R and D Program for Cancer Control (1320010) and the Ministry of Health and Welfare(MOHW) (A120340), Republic of Korea.
Publisher Copyright:
© 2017 Bentham Science Publishers.
Keywords
- Alzheimer’s disease
- Apoptosis
- HtrA2
- HtrA2 interacting proteins
- Mitochondria
- Parkinson’s disease
- Protein quality Control
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology