Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations

Keyphrases

• Amyotrophic Lateral Sclerosis 100%
• TAR DNA-binding Protein 43 (TDP-43) 100%
• SOD1 mutation 100%
• Mutant SOD1 41%
• Superoxide Dismutase 1 (SOD1) 33%
• Familial ALS 25%
• Glia 16%
• SOD1G93A Mice 16%
• Transfected Cells 8%
• Phosphorylation 8%
• Physical Interaction 8%
• Spinal Cord 8%
• Overexpression 8%
• Insolubility 8%
• Co-immunoprecipitation (co-IP) 8%
• Neurodegenerative Diseases 8%
• Detergent 8%
• Cell Apoptosis 8%
• Immunoprecipitation Assay 8%
• Pathologic 8%
• Motor Neuron 8%
• Age-dependent 8%
• Insoluble Fraction 8%
• Zn-superoxide Dismutase 8%
• Motor Neuron Disease 8%
• Neuronal Cytotoxicity 8%
• SOD1G93A 8%
• C-terminal Fragments 8%
• Adult-onset 8%
• Human Tissue Model 8%
• IPSC-derived Neurons 8%
• ALS Patients 8%
• Human Cell Models 8%
• Cytoplasmic Inclusions 8%

Neuroscience

• Amyotrophic Lateral Sclerosis 100%
• SOD1 100%
• TAR DNA Binding Protein 100%
• Motor Neuron 25%
• Glia 16%
• Cell Line 8%
• Neurodegenerative Disorder 8%
• C-Terminus 8%
• Immunoprecipitation 8%
• Cytotoxicity 8%
• Copper Zinc Superoxide Dismutase 8%

Biochemistry, Genetics and Molecular Biology

• TAR DNA Binding Protein 100%
• SOD1 100%
• Motor Neuron 25%
• Superoxide Dismutase 8%
• C-Terminus 8%
• Animal Model 8%
• Solubility 8%
• Immunoprecipitation 8%
• Cytotoxicity 8%
• Induced Pluripotent Stem Cell 8%