PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances

Sang Woo Shin; Yeon Do Jang; Kyoung Won Ko; Eun Young Kang; Jun Hyeok Han; Tarek M. Bedair; Ik Hwan Kim; Tae Il Son; Wooram Park; Dong Keun Han

doi:10.1016/j.jiec.2019.07.043

PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances

Sang Woo Shin, Yeon Do Jang, Kyoung Won Ko, Eun Young Kang, Jun Hyeok Han, Tarek M. Bedair, Ik Hwan Kim, Tae Il Son, Wooram Park, Dong Keun Han

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermal filler with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL) and MH microspheres (PCL/MH) were uniformly produced with approximately 50 μm in size through a simple fluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradation products generated by polymer degradation. In in vitro cell experiments, when MH was treated with acidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to induce wound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted the production of collagen. These results suggest that the PCL/MH microspheres have great potential as a functional dermal filler for skin esthetics and facial plastic surgery.

Original language	English
Pages (from-to)	854-861
Number of pages	8
Journal	Journal of Industrial and Engineering Chemistry
Volume	80
DOIs	https://doi.org/10.1016/j.jiec.2019.07.043
Publication status	Published - 2019 Dec 25

Keywords

Anti-inflammation
Anti-senescence
Dermal filler
Magnesium hydroxide (MH)
Polycaprolactone (PCL) microspheres

ASJC Scopus subject areas

Chemical Engineering(all)

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10.1016/j.jiec.2019.07.043

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title = "PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances",

abstract = "Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermal filler with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL) and MH microspheres (PCL/MH) were uniformly produced with approximately 50 μm in size through a simple fluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradation products generated by polymer degradation. In in vitro cell experiments, when MH was treated with acidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to induce wound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted the production of collagen. These results suggest that the PCL/MH microspheres have great potential as a functional dermal filler for skin esthetics and facial plastic surgery.",

keywords = "Anti-inflammation, Anti-senescence, Dermal filler, Magnesium hydroxide (MH), Polycaprolactone (PCL) microspheres",

author = "Shin, {Sang Woo} and Jang, {Yeon Do} and Ko, {Kyoung Won} and Kang, {Eun Young} and Han, {Jun Hyeok} and Bedair, {Tarek M.} and Kim, {Ik Hwan} and Son, {Tae Il} and Wooram Park and Han, {Dong Keun}",

note = "Funding Information: This work was supported by Basic Science Research Programs ( 2017R1A2B3011121 and 2018R1C1B6001120 ) and Bio&Medical Technology Development Program ( 2018M3A9E2024579 ) through the National Research Foundation of Korea funded by the Ministry of Science and ICT (MSIT) and Korea Health Technology R&D Project ( HI18C0089 ) through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea . Publisher Copyright: {\textcopyright} 2019 The Korean Society of Industrial and Engineering Chemistry",

year = "2019",

month = dec,

day = "25",

doi = "10.1016/j.jiec.2019.07.043",

language = "English",

volume = "80",

pages = "854--861",

journal = "Journal of Industrial and Engineering Chemistry",

issn = "1226-086X",

publisher = "Korean Society of Industrial Engineering Chemistry",

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T1 - PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances

AU - Shin, Sang Woo

AU - Jang, Yeon Do

AU - Ko, Kyoung Won

AU - Kang, Eun Young

AU - Han, Jun Hyeok

AU - Bedair, Tarek M.

AU - Kim, Ik Hwan

AU - Son, Tae Il

AU - Park, Wooram

AU - Han, Dong Keun

N1 - Funding Information: This work was supported by Basic Science Research Programs ( 2017R1A2B3011121 and 2018R1C1B6001120 ) and Bio&Medical Technology Development Program ( 2018M3A9E2024579 ) through the National Research Foundation of Korea funded by the Ministry of Science and ICT (MSIT) and Korea Health Technology R&D Project ( HI18C0089 ) through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea . Publisher Copyright: © 2019 The Korean Society of Industrial and Engineering Chemistry

PY - 2019/12/25

Y1 - 2019/12/25

N2 - Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermal filler with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL) and MH microspheres (PCL/MH) were uniformly produced with approximately 50 μm in size through a simple fluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradation products generated by polymer degradation. In in vitro cell experiments, when MH was treated with acidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to induce wound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted the production of collagen. These results suggest that the PCL/MH microspheres have great potential as a functional dermal filler for skin esthetics and facial plastic surgery.

AB - Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermal filler with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL) and MH microspheres (PCL/MH) were uniformly produced with approximately 50 μm in size through a simple fluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradation products generated by polymer degradation. In in vitro cell experiments, when MH was treated with acidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to induce wound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted the production of collagen. These results suggest that the PCL/MH microspheres have great potential as a functional dermal filler for skin esthetics and facial plastic surgery.

KW - Anti-inflammation

KW - Anti-senescence

KW - Dermal filler

KW - Magnesium hydroxide (MH)

KW - Polycaprolactone (PCL) microspheres

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JO - Journal of Industrial and Engineering Chemistry

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PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances

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Keywords

ASJC Scopus subject areas

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