Abstract
The aim of this study was to investigate whether bronchial hyperresponsiveness in adolescents with long-term asthma remission is associated with increased peak expiratory flow (PEF) variability and/or increased bronchial response to exercise (BRE). Twenty-nine adolescents with asthma remission (neither symptoms nor any medication used during the previous two years), but with persistent methacholine hyperresponsiveness (PC20 < 18 mg/mL; remission group), 29 methacholine PC20-matched adolescents with symptomatic asthma (symptomatic group), and 20 healthy subjects (control group) were studied. Subjects recorded PEF twice daily for 14 days and PEF variability, expressed as amplitude % mean, was calculated. Subjects also underwent a standardized exercise challenge; BRE was defined as a maximal % fall in FEV1 within 30 min after exercise. The mean (± SD) PEF variations in the symptomatic group and in the remission group were 12.10 ± 6.35% and 10.02 ± 4.73%, respectively, which were significantly higher than that (5.94 ± 2.44%) of the control group. On the other hand, the degree of BRE (7.36 ± 3.85%) in the remission group was significantly lower than that (22.31 ± 10.50%) of the symptomatic group, and similar to that (5.98 ± 2.70%) of the control group. Methacholine hyperresponsiveness in asthma remission during adolescence is associated with increased PEF variability but not with increased BRE.
Original language | English |
---|---|
Pages (from-to) | 17-23 |
Number of pages | 7 |
Journal | Journal of Asthma |
Volume | 42 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2005 |
Externally published | Yes |
Bibliographical note
Funding Information:ACKNOWLEDGMENTS This study was supported in part by grant (No. 04– 2002–050–0) from the Seoul National University Hospital Research Fund, and by BK 21 Project for Medicine, Dentistry and Pharmacy.
Keywords
- Adolescence
- Asthma
- Bronchial hyperresponsiveness
- Clinical remission
- Exercise challenge
- Peak expiratory flow variability
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Immunology and Allergy
- Pulmonary and Respiratory Medicine