Peak expiratory flow variability and exercise responsiveness in methacholine-hyperresponsive adolescents with asthma remission

Yull Koh Young, Hee Kang, Young Yoo, Jinho Yu, Min Nah Kyu, Keun Kim Chang

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6 Citations (Scopus)


The aim of this study was to investigate whether bronchial hyperresponsiveness in adolescents with long-term asthma remission is associated with increased peak expiratory flow (PEF) variability and/or increased bronchial response to exercise (BRE). Twenty-nine adolescents with asthma remission (neither symptoms nor any medication used during the previous two years), but with persistent methacholine hyperresponsiveness (PC20 < 18 mg/mL; remission group), 29 methacholine PC20-matched adolescents with symptomatic asthma (symptomatic group), and 20 healthy subjects (control group) were studied. Subjects recorded PEF twice daily for 14 days and PEF variability, expressed as amplitude % mean, was calculated. Subjects also underwent a standardized exercise challenge; BRE was defined as a maximal % fall in FEV1 within 30 min after exercise. The mean (± SD) PEF variations in the symptomatic group and in the remission group were 12.10 ± 6.35% and 10.02 ± 4.73%, respectively, which were significantly higher than that (5.94 ± 2.44%) of the control group. On the other hand, the degree of BRE (7.36 ± 3.85%) in the remission group was significantly lower than that (22.31 ± 10.50%) of the symptomatic group, and similar to that (5.98 ± 2.70%) of the control group. Methacholine hyperresponsiveness in asthma remission during adolescence is associated with increased PEF variability but not with increased BRE.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalJournal of Asthma
Issue number1
Publication statusPublished - 2005
Externally publishedYes

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS This study was supported in part by grant (No. 04– 2002–050–0) from the Seoul National University Hospital Research Fund, and by BK 21 Project for Medicine, Dentistry and Pharmacy.


  • Adolescence
  • Asthma
  • Bronchial hyperresponsiveness
  • Clinical remission
  • Exercise challenge
  • Peak expiratory flow variability

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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