Pep-1 peptide-modified liposomal carriers for intracellular delivery of gold nanoparticles

Myung Joo Kang; Sangyeop Lee; Bo Kyun Kim; Jae Yoon Eum; Sang Han Park; Min Hyung Kang; Chil Hwan Oh; Jaebum Choo; Young Wook Choi

doi:10.1248/cpb.59.109

Pep-1 peptide-modified liposomal carriers for intracellular delivery of gold nanoparticles

Myung Joo Kang, Sangyeop Lee, Bo Kyun Kim, Jae Yoon Eum, Sang Han Park, Min Hyung Kang, Chil Hwan Oh, Jaebum Choo, Young Wook Choi

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A Pep-1 peptide-modified liposomal (Pep1-Lipo) carrier system was investigated to increase the intracellular delivery of gold nanoparticles (Au NPs). Au NPs with a mean diameter of 13 nm were successfully encapsulated into the inner aqueous compartment of the novel carrier using an ethanol injection technique, reserving the distinctive optical characteristics of the surface plasmon resonance peak around 530 nm. The Au NP-loaded liposomal carrier was physically characterized as 150-170 nm in size and 45 mV in zeta potential. Dark field microscopic observation demonstrated that in vitro cellular association and/or translocation of the nanoprobes into the cells was increased by Pep1-Lipo carriers compared to bare Au NPs. In conclusion, this novel liposomal formulation is a promising platform for the intracellular delivery of metallic nanoprobes including Au NPs.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	1
DOIs	https://doi.org/10.1248/cpb.59.109
Publication status	Published - 2011 Jan 1

Keywords

Gold nanoparticle
Intracellular delivery
Liposome
Nanocarrier
Pep-1 peptide

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.59.109

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title = "Pep-1 peptide-modified liposomal carriers for intracellular delivery of gold nanoparticles",

abstract = "A Pep-1 peptide-modified liposomal (Pep1-Lipo) carrier system was investigated to increase the intracellular delivery of gold nanoparticles (Au NPs). Au NPs with a mean diameter of 13 nm were successfully encapsulated into the inner aqueous compartment of the novel carrier using an ethanol injection technique, reserving the distinctive optical characteristics of the surface plasmon resonance peak around 530 nm. The Au NP-loaded liposomal carrier was physically characterized as 150-170 nm in size and 45 mV in zeta potential. Dark field microscopic observation demonstrated that in vitro cellular association and/or translocation of the nanoprobes into the cells was increased by Pep1-Lipo carriers compared to bare Au NPs. In conclusion, this novel liposomal formulation is a promising platform for the intracellular delivery of metallic nanoprobes including Au NPs.",

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author = "Kang, {Myung Joo} and Sangyeop Lee and Kim, {Bo Kyun} and Eum, {Jae Yoon} and Park, {Sang Han} and Kang, {Min Hyung} and Oh, {Chil Hwan} and Jaebum Choo and Choi, {Young Wook}",

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AU - Lee, Sangyeop

AU - Kim, Bo Kyun

AU - Eum, Jae Yoon

AU - Park, Sang Han

AU - Kang, Min Hyung

AU - Oh, Chil Hwan

AU - Choo, Jaebum

AU - Choi, Young Wook

PY - 2011/1/1

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KW - Liposome

KW - Nanocarrier

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Pep-1 peptide-modified liposomal carriers for intracellular delivery of gold nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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