Peptide Assembly of Different Dimensions and Their Effect on Myoblast Proliferation

Jinwoo Hong; Taeyeon Kim; Jehan Kim; Yongju Kim

doi:10.1021/acsami.3c01482

Peptide Assembly of Different Dimensions and Their Effect on Myoblast Proliferation

Jinwoo Hong, Taeyeon Kim, Jehan Kim, Yongju Kim

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Variations in the functionalities of materials of different dimensions containing the same functional groups can be attributed to the structural stability and morphology of the materials. The morphology of peptide assemblies can influence their interactions with biological systems and ultimately modulate their bioactivity. Among reported Arg-Gly-Asp (RGD)-based supramolecular materials, two-dimensional (2-D) peptide assembly has been rarely studied. Herein, we report the fabrication of RGD-based supramolecular one-dimensional (1-D) and 2-D assemblies as peptide-based myoblast growth accelerators. The 2-D assembly was more effective in proliferating C2C12 cells than the 1-D assembly. These findings provide insights into the construction of optimal RGD-based supramolecular functional materials of different dimensions.

Original language	English
Pages (from-to)	29767-29776
Number of pages	10
Journal	ACS Applied Materials and Interfaces
Volume	15
Issue number	25
DOIs	https://doi.org/10.1021/acsami.3c01482
Publication status	Published - 2023 Jun 28

Bibliographical note

Publisher Copyright:
© 2023 American Chemical Society.

Keywords

1-D nanofibers
2-D sheets
arene−perfluoroarene interaction
myoblast proliferation
peptide assembly

ASJC Scopus subject areas

General Materials Science

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10.1021/acsami.3c01482

Cite this

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abstract = "Variations in the functionalities of materials of different dimensions containing the same functional groups can be attributed to the structural stability and morphology of the materials. The morphology of peptide assemblies can influence their interactions with biological systems and ultimately modulate their bioactivity. Among reported Arg-Gly-Asp (RGD)-based supramolecular materials, two-dimensional (2-D) peptide assembly has been rarely studied. Herein, we report the fabrication of RGD-based supramolecular one-dimensional (1-D) and 2-D assemblies as peptide-based myoblast growth accelerators. The 2-D assembly was more effective in proliferating C2C12 cells than the 1-D assembly. These findings provide insights into the construction of optimal RGD-based supramolecular functional materials of different dimensions.",

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author = "Jinwoo Hong and Taeyeon Kim and Jehan Kim and Yongju Kim",

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AU - Hong, Jinwoo

AU - Kim, Taeyeon

AU - Kim, Jehan

AU - Kim, Yongju

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Peptide Assembly of Different Dimensions and Their Effect on Myoblast Proliferation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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