Variations in the functionalities of materials of different dimensions containing the same functional groups can be attributed to the structural stability and morphology of the materials. The morphology of peptide assemblies can influence their interactions with biological systems and ultimately modulate their bioactivity. Among reported Arg-Gly-Asp (RGD)-based supramolecular materials, two-dimensional (2-D) peptide assembly has been rarely studied. Herein, we report the fabrication of RGD-based supramolecular one-dimensional (1-D) and 2-D assemblies as peptide-based myoblast growth accelerators. The 2-D assembly was more effective in proliferating C2C12 cells than the 1-D assembly. These findings provide insights into the construction of optimal RGD-based supramolecular functional materials of different dimensions.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea (NRF-2022R1F1A1075138 and NRF-2022R1A4A1031687), a Korea University grant, and the KU-KIST School Project.
© 2023 American Chemical Society.
- 1-D nanofibers
- 2-D sheets
- arene−perfluoroarene interaction
- myoblast proliferation
- peptide assembly
ASJC Scopus subject areas
- General Materials Science