Abstract
Various biological activities of peptides have been found. In this study, the induction of apoptosis in a human lymphoma cell line (U937) by peptide fraction separated from anchovy sauce was studied using biochemical and flow cytometric methods. After U937 was treated with a hydrophobic peptide fraction of the anchovy sauce, a sub-G1 peak, which represents apoptosis, was found in the cell cycle analysis. The apoptosis in the peptide-treated U937 cell was also confirmed by apoptotic DNA fragmentation. Furthermore, an increase of caspase-3 and -8 activities was observed. Our results suggest that the peptide fraction separated from the anchovy sauce may have cancer chemopreventive effects through the induction of apoptosis in cancer cells.
Original language | English |
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Pages (from-to) | 399-404 |
Number of pages | 6 |
Journal | Annals of the New York Academy of Sciences |
Volume | 1010 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- Apoptosis
- Caspase
- Fish sauce
- Lymphoma cell line
- Peptide
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science