TY - JOUR
T1 - Performance evaluation of a Compton SPECT imager for determining the position and distribution of 225Ac in targeted alpha therapy
T2 - A Monte Carlo simulation based phantom study
AU - Lee, Taewoong
AU - Kim, Minho
AU - Lee, Wonho
AU - Kim, Byoungsoo
AU - Lim, Ilhan
AU - Song, Kanghyon
AU - Kim, Jongguk
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - In this study, the performance of a Compton Single Photon Emission Computed Tomography (SPECT) imager when in vivo monitoring the position and distribution of 225Ac radionuclide in targeted alpha therapy (TAT) was evaluated. When 225Ac radionuclide, which emits various γ-rays (218 and 440 keV), is used in TAT, both the photoelectric and Compton scattering events can be used for image reconstruction. Moreover, all information pertaining to the various γ-rays of the 225Ac radionuclide can be individually or simultaneously utilized in the reconstructed image. Three types of simulation phantoms and a quantitative evaluation method were used to compare the performance of the Compton SPECT imager to that of conventional SPECT imaging, which uses only photoelectric events, and the results demonstrated that the Compton SPECT imager exhibited a higher performance as the effective count for the image reconstruction was higher. To verify the accuracy of the position and distribution of the 225Ac radionuclide that had been inserted into the phantom, reconstructed images of the various γ-rays were combined with cross-sectional images of the human phantom and all combined images were found to match the predetermined simulation conditions. In conclusion, the simulation results demonstrated the feasibility of the in vivo monitoring of the position and distribution of 225Ac radionuclide using the γ-rays in TAT.
AB - In this study, the performance of a Compton Single Photon Emission Computed Tomography (SPECT) imager when in vivo monitoring the position and distribution of 225Ac radionuclide in targeted alpha therapy (TAT) was evaluated. When 225Ac radionuclide, which emits various γ-rays (218 and 440 keV), is used in TAT, both the photoelectric and Compton scattering events can be used for image reconstruction. Moreover, all information pertaining to the various γ-rays of the 225Ac radionuclide can be individually or simultaneously utilized in the reconstructed image. Three types of simulation phantoms and a quantitative evaluation method were used to compare the performance of the Compton SPECT imager to that of conventional SPECT imaging, which uses only photoelectric events, and the results demonstrated that the Compton SPECT imager exhibited a higher performance as the effective count for the image reconstruction was higher. To verify the accuracy of the position and distribution of the 225Ac radionuclide that had been inserted into the phantom, reconstructed images of the various γ-rays were combined with cross-sectional images of the human phantom and all combined images were found to match the predetermined simulation conditions. In conclusion, the simulation results demonstrated the feasibility of the in vivo monitoring of the position and distribution of 225Ac radionuclide using the γ-rays in TAT.
KW - Ac radionuclide
KW - Compton SPECT imaging
KW - Targeted alpha therapy (TAT)
UR - http://www.scopus.com/inward/record.url?scp=85072680640&partnerID=8YFLogxK
U2 - 10.1016/j.apradiso.2019.108893
DO - 10.1016/j.apradiso.2019.108893
M3 - Article
C2 - 31574432
AN - SCOPUS:85072680640
SN - 0969-8043
VL - 154
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
M1 - 108893
ER -