Performance Evaluation of STANDARD Q COVID/FLU Ag Combo for Detection of SARS-CoV-2 and Influenza A/B

Kristin Widyasari, Soomin Kim, Sunjoo Kim, Chae Seung Lim

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We evaluated the performance of the STANDARD Q COVID/FLU Ag Combo test (Q Ag combo test) for the detection of SARS-CoV-2, influenza A, and influenza B using a single point-of-care device compared with real-time PCR. A total of 408 individuals, 55 positives with SARS-CoV-2, 90 with influenza A, 68 with influenza B, and 195 negatives for all viruses, participated. The Q Ag combo test demonstrated a high level of sensitivity of 92.73% and a specificity of 99.49% for the detection of SARS-CoV-2. When the number of days from symptom onset (DSO) was restricted to 0 < DSO ≤ 6, the sensitivity of the Q Ag combo test to detect SARS-CoV-2 was 100%, and when the Ct value of RdRp was ≤20, the sensitivity to detect SARS-CoV-2 was 93.10%. The Q Ag combo test results also demonstrated a sensitivity of 92.22% and a specificity of 100% for influenza A, a sensitivity of 91.18%, and a specificity of 99.49% for influenza B. The agreement analysis of the Q Ag combo test with the RT-PCR results demonstrated excellent outcomes, making it useful and efficient for the detection of SARS-CoV-2, influenza A, and influenza B.

Original languageEnglish
Article number32
JournalDiagnostics
Volume13
Issue number1
DOIs
Publication statusPublished - 2023 Jan

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

  • SARS-CoV-2
  • influenza A
  • influenza B
  • point-of-care
  • rapid antigen test

ASJC Scopus subject areas

  • Clinical Biochemistry

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