Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication

Jeong Yoon Choi; Young Min Park; Yeon Sun Woo; Sung Un Kim; Jin Man Jung; Do Young Kwon

doi:10.1016/j.jns.2013.12.007

Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication

Jeong Yoon Choi, Young Min Park, Yeon Sun Woo, Sung Un Kim, Jin Man Jung, Do Young Kwon

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central nervous system, decreased excitatory inputs from the brainstem may lead to cerebellar dysfunction, causing perverted head-shaking and positional downbeat nystagmus.

Original language	English
Pages (from-to)	243-244
Number of pages	2
Journal	Journal of the Neurological Sciences
Volume	337
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2013.12.007
Publication status	Published - 2014 Feb 15

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central nervous system, decreased excitatory inputs from the brainstem may lead to cerebellar dysfunction, causing perverted head-shaking and positional downbeat nystagmus.",

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AU - Woo, Yeon Sun

AU - Kim, Sung Un

AU - Jung, Jin Man

AU - Kwon, Do Young

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AB - Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central nervous system, decreased excitatory inputs from the brainstem may lead to cerebellar dysfunction, causing perverted head-shaking and positional downbeat nystagmus.

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Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication

Abstract

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