pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Woo Sun Shim; Jong Ho Kim; Kwangmeyung Kim; Yoo Shin Kim; Rang Woon Park; In San Kim; Ick Chan Kwon; Doo Sung Lee

doi:10.1016/j.ijpharm.2006.09.027

pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Woo Sun Shim, Jong Ho Kim, Kwangmeyung Kim, Yoo Shin Kim, Rang Woon Park, In San Kim, Ick Chan Kwon, Doo Sung Lee

Research output: Contribution to journal › Article › peer-review

125 Citations (Scopus)

Abstract

Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

Original language	English
Pages (from-to)	11-18
Number of pages	8
Journal	International Journal of Pharmaceutics
Volume	331
Issue number	1
DOIs	https://doi.org/10.1016/j.ijpharm.2006.09.027
Publication status	Published - 2007 Feb 22

Bibliographical note

Funding Information:
This work was supported by grant no. R01-2006-000-10629-0 from the Basic Research Program of the Korean Science & Engineering Foundation and Real-Time Imaging project of KIST Intramural Research Program.

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

In vivo anti-tumor effect
Injectable hydrogel
Paclitaxel
TUNEL assay
pH/T-sensitive block copolymer hydrogel

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.ijpharm.2006.09.027

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title = "pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel",

abstract = "Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.",

keywords = "In vivo anti-tumor effect, Injectable hydrogel, Paclitaxel, TUNEL assay, pH/T-sensitive block copolymer hydrogel",

author = "Shim, {Woo Sun} and Kim, {Jong Ho} and Kwangmeyung Kim and Kim, {Yoo Shin} and Park, {Rang Woon} and Kim, {In San} and Kwon, {Ick Chan} and Lee, {Doo Sung}",

note = "Funding Information: This work was supported by grant no. R01-2006-000-10629-0 from the Basic Research Program of the Korean Science & Engineering Foundation and Real-Time Imaging project of KIST Intramural Research Program. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.ijpharm.2006.09.027",

language = "English",

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AU - Shim, Woo Sun

AU - Kim, Jong Ho

AU - Kim, Kwangmeyung

AU - Kim, Yoo Shin

AU - Park, Rang Woon

AU - Kim, In San

AU - Kwon, Ick Chan

AU - Lee, Doo Sung

N1 - Funding Information: This work was supported by grant no. R01-2006-000-10629-0 from the Basic Research Program of the Korean Science & Engineering Foundation and Real-Time Imaging project of KIST Intramural Research Program. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2007/2/22

Y1 - 2007/2/22

N2 - Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

AB - Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

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KW - TUNEL assay

KW - pH/T-sensitive block copolymer hydrogel

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pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Abstract

Bibliographical note

Keywords

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