PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

Jin Young Ko; Sangjin Park; Hyejung Lee; Heebeom Koo; Min Sang Kim; Kuiwon Choi; Ick Chan Kwon; Seo Young Jeong; Kwangmeyung Kim; Doo Sung Lee

doi:10.1002/smll.201001252

PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

Jin Young Ko, Sangjin Park, Hyejung Lee, Heebeom Koo, Min Sang Kim, Kuiwon Choi, Ick Chan Kwon, Seo Young Jeong, Kwangmeyung Kim, Doo Sung Lee

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

Original language	English
Pages (from-to)	2539-2544
Number of pages	6
Journal	Small
Volume	6
Issue number	22
DOIs	https://doi.org/10.1002/smll.201001252
Publication status	Published - 2010 Nov 22

Keywords

block copolymers
fluorescent probes
micelles
nanoparticles
tumor imaging

ASJC Scopus subject areas

Biotechnology
General Chemistry
Biomaterials
General Materials Science

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10.1002/smll.201001252

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title = "PH-sensitive nanoflash for tumoral acidic pH imaging in live animals",

abstract = "Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.",

keywords = "block copolymers, fluorescent probes, micelles, nanoparticles, tumor imaging",

author = "Ko, {Jin Young} and Sangjin Park and Hyejung Lee and Heebeom Koo and Kim, {Min Sang} and Kuiwon Choi and Kwon, {Ick Chan} and Jeong, {Seo Young} and Kwangmeyung Kim and Lee, {Doo Sung}",

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T1 - PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

AU - Ko, Jin Young

AU - Park, Sangjin

AU - Lee, Hyejung

AU - Koo, Heebeom

AU - Kim, Min Sang

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Jeong, Seo Young

AU - Kim, Kwangmeyung

AU - Lee, Doo Sung

PY - 2010/11/22

Y1 - 2010/11/22

N2 - Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

AB - Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

KW - block copolymers

KW - fluorescent probes

KW - micelles

KW - nanoparticles

KW - tumor imaging

UR - http://www.scopus.com/inward/record.url?scp=78649666582&partnerID=8YFLogxK

U2 - 10.1002/smll.201001252

DO - 10.1002/smll.201001252

M3 - Article

C2 - 20979241

AN - SCOPUS:78649666582

SN - 1613-6810

VL - 6

SP - 2539

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JO - Small

JF - Small

IS - 22

ER -

PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

Abstract

Keywords

ASJC Scopus subject areas

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