PH sensitivity of carbon dioxide conversion catalyzed by isocitrate dehydrogenase

Shunxiang Xia, Ping Wang, Jungbae Kim

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Biological conversion of carbon dioxide has been examined with growing interest in recent years for its potential in reduction of greenhouse gas emission. While many conversion routes have been suggested and demonstrated, understanding the constraints and limits of such reaction routes, either in vivo or in vitro, is becoming increasingly important. The current work examines the pH sensitivity of the reaction catalyzed by isocitrate dehydrogenase with respect to its potentials in carbon capture and conversion via both experimental measurements and theoretical analysis. As a result, the reaction equilibrium constant determined experimentally shifted by a factor of ∼500-fold when pH changed between 5 and 9. Thermodynamic analysis agreed well with such a pH sensitivity, indicating the impact of pH on Gibbs free energy of the species involved in the reaction helped to shift the reaction equilibrium.

    Original languageEnglish
    Pages (from-to)102-107
    Number of pages6
    JournalGreenhouse Gases: Science and Technology
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - 2015 Feb 1

    Bibliographical note

    Publisher Copyright:
    © 2014 Society of Chemical Industry and John Wiley & Sons, Ltd.

    Keywords

    • biocatalysis
    • biosynthesis
    • carbon conversion
    • carbon dioxide
    • isocitrate dehydrogenase

    ASJC Scopus subject areas

    • Environmental Engineering
    • Environmental Chemistry

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