Pharmacologic treatment of acute kidney injury: Why drugs haven't worked and what is on the horizon

Sang Kyung Jo; Mitchell H. Rosner; Mark D. Okusa

doi:10.2215/CJN.03280906

Pharmacologic treatment of acute kidney injury: Why drugs haven't worked and what is on the horizon

Sang Kyung Jo, Mitchell H. Rosner, Mark D. Okusa

Research output: Contribution to journal › Short survey › peer-review

221 Citations (Scopus)

Abstract

Current strategies to limit the extent of injury in acute renal failure are based on extensive studies that identified cellular and molecular mechanisms of acute kidney injury. Despite successes in various animal models, translation to human studies has failed or studies are inconclusive. This review describes past failures and barriers to successful clinical trials. It also focuses on promising preclinical studies using novel compounds that currently are in or close to human investigation. Implementation of previous or novel compounds in well-designed clinical trials provides hope for the successful treatment of this devastating disorder.

Original language	English
Pages (from-to)	356-365
Number of pages	10
Journal	Clinical Journal of the American Society of Nephrology
Volume	2
Issue number	2
DOIs	https://doi.org/10.2215/CJN.03280906
Publication status	Published - 2007 Mar
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Critical Care and Intensive Care Medicine
Nephrology
Transplantation

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Pharmacologic treatment of acute kidney injury: Why drugs haven't worked and what is on the horizon

Abstract

ASJC Scopus subject areas

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