Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

Ji Sang Hwang; Seon A. Lee; Seong Su Hong; Xiang Hua Han; Chul Lee; Shin Jung Kang; Dongho Lee; Youngsoo Kim; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2010.04.054

Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

Ji Sang Hwang, Seon A. Lee, Seong Su Hong, Xiang Hua Han, Chul Lee, Shin Jung Kang, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC₅₀ values ranging from 9.6 μM to 35.7 μM.

Original language	English
Pages (from-to)	3785-3787
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2010.04.054
Publication status	Published - 2010

Keywords

Bibenzyl
Dendrobium nobile
Nitric oxide inhibitor
Orchidaceae
Phenanthrene

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2010.04.054

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Hwang, J. S., Lee, S. A., Hong, S. S., Han, X. H., Lee, C., Kang, S. J., Lee, D., Kim, Y., Hong, J. T., Lee, M. K., & Hwang, B. Y. (2010). Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells. Bioorganic and Medicinal Chemistry Letters, 20(12), 3785-3787. https://doi.org/10.1016/j.bmcl.2010.04.054

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title = "Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells",

abstract = "Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC50 values ranging from 9.6 μM to 35.7 μM.",

keywords = "Bibenzyl, Dendrobium nobile, Nitric oxide inhibitor, Orchidaceae, Phenanthrene",

author = "Hwang, {Ji Sang} and Lee, {Seon A.} and Hong, {Seong Su} and Han, {Xiang Hua} and Chul Lee and Kang, {Shin Jung} and Dongho Lee and Youngsoo Kim and Hong, {Jin Tae} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant (MRC, R13-2008-001-00000-00 ) and the grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Chungbuk BIT Research-Oriented University Consortium). We thank the Korea Basic Science Institute for providing certain instruments used in this study.",

year = "2010",

doi = "10.1016/j.bmcl.2010.04.054",

language = "English",

volume = "20",

pages = "3785--3787",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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number = "12",

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T1 - Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

AU - Hwang, Ji Sang

AU - Lee, Seon A.

AU - Hong, Seong Su

AU - Han, Xiang Hua

AU - Lee, Chul

AU - Kang, Shin Jung

AU - Lee, Dongho

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant (MRC, R13-2008-001-00000-00 ) and the grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Chungbuk BIT Research-Oriented University Consortium). We thank the Korea Basic Science Institute for providing certain instruments used in this study.

PY - 2010

Y1 - 2010

N2 - Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC50 values ranging from 9.6 μM to 35.7 μM.

AB - Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC50 values ranging from 9.6 μM to 35.7 μM.

KW - Bibenzyl

KW - Dendrobium nobile

KW - Nitric oxide inhibitor

KW - Orchidaceae

KW - Phenanthrene

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U2 - 10.1016/j.bmcl.2010.04.054

DO - 10.1016/j.bmcl.2010.04.054

M3 - Article

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AN - SCOPUS:77954214887

SN - 0960-894X

VL - 20

SP - 3785

EP - 3787

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

Abstract

Keywords

ASJC Scopus subject areas

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