Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation

Jung Rae Rho; Buyng Su Hwang; Seewon Joung; Mi Ran Byun; Jeong Ho Hong; Hee Yoon Lee

doi:10.1021/ol1029386

Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation

Jung Rae Rho, Buyng Su Hwang, Seewon Joung, Mi Ran Byun, Jeong Ho Hong, Hee Yoon Lee

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.(Figure Presented)

Original language	English
Pages (from-to)	884-887
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	5
DOIs	https://doi.org/10.1021/ol1029386
Publication status	Published - 2011 Mar 4

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol1029386

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AU - Joung, Seewon

AU - Byun, Mi Ran

AU - Hong, Jeong Ho

AU - Lee, Hee Yoon

PY - 2011/3/4

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Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation

Abstract

ASJC Scopus subject areas

UN SDGs

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