Phospholipase Cγ1 inhibitory activities of prenylated flavonoids isolated from Erythrina senegalensis

Won Keun Oh; Bo Yeon Kim; Hyuncheol Oh; Beom Seok Kim; Jong Seog Ahn

doi:10.1055/s-2005-864183

Phospholipase Cγ1 inhibitory activities of prenylated flavonoids isolated from Erythrina senegalensis

Won Keun Oh, Bo Yeon Kim, Hyuncheol Oh, Beom Seok Kim, Jong Seog Ahn

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Prenylated flavonoids isolated from Erythrina senegalensis were evaluated for their ability to inhibit PLCγ1 activity in vitro and the formation of inositol phosphates (IPt) in PLCγ1-overexpressing NIH3T3 fibroblast cells (NIH3T3γ1 cells). These flavonoids inhibited PLCγ1 activity in a dose-dependent manner (IC₅₀ values ranged from 1.0 μg/mL to 35.0 μg/mL) with the exception of alpinumisoflavone (5). Also erysenegalensein D (2) and erysenegalensein N (3) showed inhibition of inositol phosphate formation in NIH3T3γ1 cells with IC₅₀ values of 13.0 μg/mL and 10 μg/mL, respectively. Analyzing the relation of structure to activity, the number of prenyl groups and the hydroxylation of the prenyl groups were important factors for the inhibition of PLCγ1 activity and of inositol phosphate formation.

Original language	English
Pages (from-to)	780-782
Number of pages	3
Journal	Planta Medica
Volume	71
Issue number	8
DOIs	https://doi.org/10.1055/s-2005-864183
Publication status	Published - 2005 Aug
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Phospholipase Cγ1 inhibitory activities of prenylated flavonoids isolated from Erythrina senegalensis",

abstract = "Prenylated flavonoids isolated from Erythrina senegalensis were evaluated for their ability to inhibit PLCγ1 activity in vitro and the formation of inositol phosphates (IPt) in PLCγ1-overexpressing NIH3T3 fibroblast cells (NIH3T3γ1 cells). These flavonoids inhibited PLCγ1 activity in a dose-dependent manner (IC50 values ranged from 1.0 μg/mL to 35.0 μg/mL) with the exception of alpinumisoflavone (5). Also erysenegalensein D (2) and erysenegalensein N (3) showed inhibition of inositol phosphate formation in NIH3T3γ1 cells with IC50 values of 13.0 μg/mL and 10 μg/mL, respectively. Analyzing the relation of structure to activity, the number of prenyl groups and the hydroxylation of the prenyl groups were important factors for the inhibition of PLCγ1 activity and of inositol phosphate formation.",

author = "Oh, {Won Keun} and Kim, {Bo Yeon} and Hyuncheol Oh and Kim, {Beom Seok} and Ahn, {Jong Seog}",

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AU - Oh, Won Keun

AU - Kim, Bo Yeon

AU - Oh, Hyuncheol

AU - Kim, Beom Seok

AU - Ahn, Jong Seog

PY - 2005/8

Y1 - 2005/8

N2 - Prenylated flavonoids isolated from Erythrina senegalensis were evaluated for their ability to inhibit PLCγ1 activity in vitro and the formation of inositol phosphates (IPt) in PLCγ1-overexpressing NIH3T3 fibroblast cells (NIH3T3γ1 cells). These flavonoids inhibited PLCγ1 activity in a dose-dependent manner (IC50 values ranged from 1.0 μg/mL to 35.0 μg/mL) with the exception of alpinumisoflavone (5). Also erysenegalensein D (2) and erysenegalensein N (3) showed inhibition of inositol phosphate formation in NIH3T3γ1 cells with IC50 values of 13.0 μg/mL and 10 μg/mL, respectively. Analyzing the relation of structure to activity, the number of prenyl groups and the hydroxylation of the prenyl groups were important factors for the inhibition of PLCγ1 activity and of inositol phosphate formation.

AB - Prenylated flavonoids isolated from Erythrina senegalensis were evaluated for their ability to inhibit PLCγ1 activity in vitro and the formation of inositol phosphates (IPt) in PLCγ1-overexpressing NIH3T3 fibroblast cells (NIH3T3γ1 cells). These flavonoids inhibited PLCγ1 activity in a dose-dependent manner (IC50 values ranged from 1.0 μg/mL to 35.0 μg/mL) with the exception of alpinumisoflavone (5). Also erysenegalensein D (2) and erysenegalensein N (3) showed inhibition of inositol phosphate formation in NIH3T3γ1 cells with IC50 values of 13.0 μg/mL and 10 μg/mL, respectively. Analyzing the relation of structure to activity, the number of prenyl groups and the hydroxylation of the prenyl groups were important factors for the inhibition of PLCγ1 activity and of inositol phosphate formation.

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Phospholipase Cγ1 inhibitory activities of prenylated flavonoids isolated from Erythrina senegalensis

Abstract

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