Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade

Soon Young Shin; Ha Young Choi; Bong Hyun Ahn; Do Sik Min; Sang Wook Son; Young Han Lee

doi:10.1016/j.bbrc.2006.12.064

Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade

Soon Young Shin, Ha Young Choi, Bong Hyun Ahn, Do Sik Min, Sang Wook Son, Young Han Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.

Original language	English
Pages (from-to)	611-616
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	353
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2006.12.064
Publication status	Published - 2007 Feb 16

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant (KRF-2003-041-E00051) and by the research fund of Hanyang University (HY-2005-I). We thank Mr. Tae-Seop Shin for preparation of the MMP-3 promoter constructs.

Keywords

MAPK
MMP-3
PLCγ1
Protein kinase C

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2006.12.064

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title = "Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade",

abstract = "The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.",

keywords = "MAPK, MMP-3, PLCγ1, Protein kinase C",

author = "Shin, {Soon Young} and Choi, {Ha Young} and Ahn, {Bong Hyun} and Min, {Do Sik} and Son, {Sang Wook} and Lee, {Young Han}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2003-041-E00051) and by the research fund of Hanyang University (HY-2005-I). We thank Mr. Tae-Seop Shin for preparation of the MMP-3 promoter constructs.",

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T1 - Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade

AU - Shin, Soon Young

AU - Choi, Ha Young

AU - Ahn, Bong Hyun

AU - Min, Do Sik

AU - Son, Sang Wook

AU - Lee, Young Han

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2003-041-E00051) and by the research fund of Hanyang University (HY-2005-I). We thank Mr. Tae-Seop Shin for preparation of the MMP-3 promoter constructs.

PY - 2007/2/16

Y1 - 2007/2/16

N2 - The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.

AB - The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.

KW - MAPK

KW - MMP-3

KW - PLCγ1

KW - Protein kinase C

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U2 - 10.1016/j.bbrc.2006.12.064

DO - 10.1016/j.bbrc.2006.12.064

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AN - SCOPUS:33846000588

SN - 0006-291X

VL - 353

SP - 611

EP - 616

JO - Biochemical and biophysical research communications

JF - Biochemical and biophysical research communications

IS - 3

ER -

Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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