Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells

Hee Jung Yang; Hyesook Youn; Ki Moon Seong; Young Woo Jin; Joon Kim; Buhyun Youn

doi:10.1074/jbc.M112.385989

Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells

Hee Jung Yang, Hyesook Youn, Ki Moon Seong, Young Woo Jin, Joon Kim, Buhyun Youn

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.

Original language	English
Pages (from-to)	2965-2975
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	5
DOIs	https://doi.org/10.1074/jbc.M112.385989
Publication status	Published - 2013 Feb 1

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.385989

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abstract = "Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.",

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AU - Yang, Hee Jung

AU - Youn, Hyesook

AU - Seong, Ki Moon

AU - Jin, Young Woo

AU - Kim, Joon

AU - Youn, Buhyun

PY - 2013/2/1

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AB - Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.

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Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells

Abstract

ASJC Scopus subject areas

UN SDGs

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