Abstract
Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.
Original language | English |
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Pages (from-to) | 2965-2975 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2013 Feb 1 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology