Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells

Hee Jung Yang; Hyesook Youn; Ki Moon Seong; Young Woo Jin; Joon Kim; Buhyun Youn

doi:10.1074/jbc.M112.385989

Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells

Hee Jung Yang
, Hyesook Youn
, Ki Moon Seong
, Young Woo Jin
, Joon Kim
, Buhyun Youn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.

Original language	English
Pages (from-to)	2965-2975
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	5
DOIs	https://doi.org/10.1074/jbc.M112.385989
Publication status	Published - 2013 Feb 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.385989

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title = "Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells",

abstract = "Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.",

author = "Yang, \{Hee Jung\} and Hyesook Youn and Seong, \{Ki Moon\} and Jin, \{Young Woo\} and Joon Kim and Buhyun Youn",

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T1 - Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells

AU - Yang, Hee Jung

AU - Youn, Hyesook

AU - Seong, Ki Moon

AU - Jin, Young Woo

AU - Kim, Joon

AU - Youn, Buhyun

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.

AB - Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.

UR - https://www.scopus.com/pages/publications/84873324354

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DO - 10.1074/jbc.M112.385989

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VL - 288

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EP - 2975

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 5

ER -

Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells

Abstract

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