Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy

Jingjing Han; Hyunchul Kang; Xingshu Li; Nahyun Kwon; Haidong Li; Sungnam Park; Juyoung Yoon

doi:10.1021/acsanm.1c00843

Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy

Jingjing Han, Hyunchul Kang, Xingshu Li, Nahyun Kwon, Haidong Li, Sungnam Park, Juyoung Yoon

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Nanoparticle-based enzyme mimics have fewer applications in ferrotherapy so far. The limited number of integrated biomimetic architectures satisfy biobuilding blocks and adaptability in the high efficiency of ferrotherapy requirements. Herein, we develop a minimal nanoparticle as an efficient photodynamic ferrotherapy agent, which is constructed through ferrous-coordination-driven cyanine-based amino acid assembly. In comparison with a free photosensitizer, this nanoparticle (photofenozyme) composed of Fe-containing cores and serum protein shells is fabricated. And it has a high light-harvesting ability, and a higher intersystem crossing (ISC) rate constant (4.41 × 1011 s-1 versus 1.17 × 106 s-1), which benefits efficient production of the triplet state. The photofenozyme allows adaptive photo-Fenton-like activity based on the different radical generations. And they further trigger and photoenhance efficient ferroptosis. This work provides insights into optimizing current photosensitizers to generate an adaptive supramolecular photocatalyst and presents a promising strategy to design multifunctional nanozyme theranostics.

Original language	English
Pages (from-to)	5954-5962
Number of pages	9
Journal	ACS Applied Nano Materials
Volume	4
Issue number	6
DOIs	https://doi.org/10.1021/acsanm.1c00843
Publication status	Published - 2021 Jun 25

Bibliographical note

Funding Information:
This study was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and No. 2019R1A6A1A11044070 for S.P.).

Funding Information:
We acknowledge financial support from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and No. 2019R1A6A1A11044070 for S.P.).

Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.

Keywords

Fe(II)-coordination-driven Co-assembly
ferrotherapeutic agent
photosensitive nanoparticles
photosensitizer
self-evolution

ASJC Scopus subject areas

General Materials Science

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10.1021/acsanm.1c00843

Cite this

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title = "Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy",

abstract = "Nanoparticle-based enzyme mimics have fewer applications in ferrotherapy so far. The limited number of integrated biomimetic architectures satisfy biobuilding blocks and adaptability in the high efficiency of ferrotherapy requirements. Herein, we develop a minimal nanoparticle as an efficient photodynamic ferrotherapy agent, which is constructed through ferrous-coordination-driven cyanine-based amino acid assembly. In comparison with a free photosensitizer, this nanoparticle (photofenozyme) composed of Fe-containing cores and serum protein shells is fabricated. And it has a high light-harvesting ability, and a higher intersystem crossing (ISC) rate constant (4.41 × 1011 s-1 versus 1.17 × 106 s-1), which benefits efficient production of the triplet state. The photofenozyme allows adaptive photo-Fenton-like activity based on the different radical generations. And they further trigger and photoenhance efficient ferroptosis. This work provides insights into optimizing current photosensitizers to generate an adaptive supramolecular photocatalyst and presents a promising strategy to design multifunctional nanozyme theranostics. ",

keywords = "Fe(II)-coordination-driven Co-assembly, ferrotherapeutic agent, photosensitive nanoparticles, photosensitizer, self-evolution",

author = "Jingjing Han and Hyunchul Kang and Xingshu Li and Nahyun Kwon and Haidong Li and Sungnam Park and Juyoung Yoon",

note = "Funding Information: This study was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and No. 2019R1A6A1A11044070 for S.P.). Funding Information: We acknowledge financial support from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and No. 2019R1A6A1A11044070 for S.P.). Publisher Copyright: {\textcopyright} 2021 American Chemical Society. All rights reserved.",

year = "2021",

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doi = "10.1021/acsanm.1c00843",

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AU - Li, Xingshu

AU - Kwon, Nahyun

AU - Li, Haidong

AU - Park, Sungnam

AU - Yoon, Juyoung

N1 - Funding Information: This study was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and No. 2019R1A6A1A11044070 for S.P.). Funding Information: We acknowledge financial support from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and No. 2019R1A6A1A11044070 for S.P.). Publisher Copyright: © 2021 American Chemical Society. All rights reserved.

PY - 2021/6/25

Y1 - 2021/6/25

N2 - Nanoparticle-based enzyme mimics have fewer applications in ferrotherapy so far. The limited number of integrated biomimetic architectures satisfy biobuilding blocks and adaptability in the high efficiency of ferrotherapy requirements. Herein, we develop a minimal nanoparticle as an efficient photodynamic ferrotherapy agent, which is constructed through ferrous-coordination-driven cyanine-based amino acid assembly. In comparison with a free photosensitizer, this nanoparticle (photofenozyme) composed of Fe-containing cores and serum protein shells is fabricated. And it has a high light-harvesting ability, and a higher intersystem crossing (ISC) rate constant (4.41 × 1011 s-1 versus 1.17 × 106 s-1), which benefits efficient production of the triplet state. The photofenozyme allows adaptive photo-Fenton-like activity based on the different radical generations. And they further trigger and photoenhance efficient ferroptosis. This work provides insights into optimizing current photosensitizers to generate an adaptive supramolecular photocatalyst and presents a promising strategy to design multifunctional nanozyme theranostics.

AB - Nanoparticle-based enzyme mimics have fewer applications in ferrotherapy so far. The limited number of integrated biomimetic architectures satisfy biobuilding blocks and adaptability in the high efficiency of ferrotherapy requirements. Herein, we develop a minimal nanoparticle as an efficient photodynamic ferrotherapy agent, which is constructed through ferrous-coordination-driven cyanine-based amino acid assembly. In comparison with a free photosensitizer, this nanoparticle (photofenozyme) composed of Fe-containing cores and serum protein shells is fabricated. And it has a high light-harvesting ability, and a higher intersystem crossing (ISC) rate constant (4.41 × 1011 s-1 versus 1.17 × 106 s-1), which benefits efficient production of the triplet state. The photofenozyme allows adaptive photo-Fenton-like activity based on the different radical generations. And they further trigger and photoenhance efficient ferroptosis. This work provides insights into optimizing current photosensitizers to generate an adaptive supramolecular photocatalyst and presents a promising strategy to design multifunctional nanozyme theranostics.

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Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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