TY - JOUR
T1 - Photodynamic therapy for hypoxic tumors
T2 - Advances and perspectives
AU - Huang, Li
AU - Zhao, Shaojing
AU - Wu, Jiasheng
AU - Yu, Le
AU - Singh, Nem
AU - Yang, Ke
AU - Lan, Minhuan
AU - Wang, Pengfei
AU - Kim, Jong Seung
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China (No. 61805287), Natural Science Foundation of Hunan Province, China (2019JJ50824), Fundamental Research Funds for the Central South Universities (No. 2020CX021), Fundamental Research Funds for the Central South Universities (Nos. 2019zzts126, 2020zzts407). This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI Project Nos. 2018R1A3B1052702 and 2019M3E5D1A01068998, J.S.K.)
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Photodynamic therapy (PDT) has been a preferred clinical technology for treating superficial tumors due to its advantages of high selectivity, non-invasiveness and negligible drug resistance. However, the hypoxic tumor microenvironment weakens the efficiency of O2-dependent PDT. Moreover, the PDT process consumes a large amount of O2 and destroys the tumor blood vessels and further blocks the O2 supply to tumor sites. Therefore, developing more advanced materials and methods for PDT of the hypoxic tumor is an essential scientific significance. This tutorial review summarizes the strategies for improving the efficacy of PDT in hypoxic tumor therapy, which is categorized into three sections: (I) enhancing O2 concentration in the tumor; (II) disregarding hypoxia; and (III) exploiting hypoxia. The advantages of combining PDT with other therapeutics, such as chemotherapy, chemo-dynamic therapy, gas therapy, immunotherapy and gene therapy, are also demonstrated. Finally, the existing challenges and future perspectives on clinical PDT for hypoxic tumors are discussed.
AB - Photodynamic therapy (PDT) has been a preferred clinical technology for treating superficial tumors due to its advantages of high selectivity, non-invasiveness and negligible drug resistance. However, the hypoxic tumor microenvironment weakens the efficiency of O2-dependent PDT. Moreover, the PDT process consumes a large amount of O2 and destroys the tumor blood vessels and further blocks the O2 supply to tumor sites. Therefore, developing more advanced materials and methods for PDT of the hypoxic tumor is an essential scientific significance. This tutorial review summarizes the strategies for improving the efficacy of PDT in hypoxic tumor therapy, which is categorized into three sections: (I) enhancing O2 concentration in the tumor; (II) disregarding hypoxia; and (III) exploiting hypoxia. The advantages of combining PDT with other therapeutics, such as chemotherapy, chemo-dynamic therapy, gas therapy, immunotherapy and gene therapy, are also demonstrated. Finally, the existing challenges and future perspectives on clinical PDT for hypoxic tumors are discussed.
KW - Photodynamic therapy
KW - Reactive oxygen species
KW - Theranostic agents
KW - Tumor hypoxia
UR - http://www.scopus.com/inward/record.url?scp=85102846137&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2021.213888
DO - 10.1016/j.ccr.2021.213888
M3 - Review article
AN - SCOPUS:85102846137
SN - 0010-8545
VL - 438
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 213888
ER -