Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

Yong Doo Park; Nicola Tirelli; Jeffrey A. Hubbell

doi:10.1016/S0142-9612(02)00420-9

Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

Yong Doo Park, Nicola Tirelli, Jeffrey A. Hubbell

Research output: Contribution to journal › Article › peer-review

316 Citations (Scopus)

Abstract

Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7d, showing adhesion and proliferation only with incorporated RGD.

Original language	English
Pages (from-to)	893-900
Number of pages	8
Journal	Biomaterials
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/S0142-9612(02)00420-9
Publication status	Published - 2003 Mar
Externally published	Yes

Keywords

Cell adhesion
Hyaluronic acid
Hydrogels
Photopolymerization
RGD

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/S0142-9612(02)00420-9

Cite this

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title = "Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks",

abstract = "Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7d, showing adhesion and proliferation only with incorporated RGD.",

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AU - Park, Yong Doo

AU - Tirelli, Nicola

AU - Hubbell, Jeffrey A.

PY - 2003/3

Y1 - 2003/3

N2 - Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7d, showing adhesion and proliferation only with incorporated RGD.

AB - Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7d, showing adhesion and proliferation only with incorporated RGD.

KW - Cell adhesion

KW - Hyaluronic acid

KW - Hydrogels

KW - Photopolymerization

KW - RGD

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JO - Biomaterials

JF - Biomaterials

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ER -

Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

Abstract

Keywords

ASJC Scopus subject areas

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