Physiological effects of yeast hydrolysate SCP-20

When the yeast hydrolysate SCP-20 from Saccharomyces cerevisiae ingested to the rat to identify the effect on anti-stress, SCP-20 have an potent effect on the weight of adrenal, spleen, kidney and thyroid, and the glutamic pyruvic transaminase (GOT), glutamic oxaloacetic transaminse (GPT) and lactic dehydrogenase (LDH) activity recovered as much as the non-stress level. In addition, the swimming time was significantly increased in the group to administer SCP-20. It is assumed that anti-fatigue effect might relate to the resistance effect on the stress induced intensive exercise. SCP-20 stimulated not only the activation of macrophage (1.9-fold of saline control) but also IL-6 production (1.9-fold) at 2.0 g/kg/day. By the culture supernatant of Peyer's patch cells from C3H/HeJ mice fed SCP-20 at 2.0 g/kg/day for 7 days, the bone marrow cells significantly proliferated as 2.1 fold to compare with those of mice received only saline (control). In addition, the contents of IL-6 in the culture supernatant of Peyer's patch cells from mice fed SCP 20 at 2.0 g/kg per day were increased in the comparison with those from control (2.3-fold).