Placental transfer of persistent organic pollutants and feasibility using the placenta as a non-invasive biomonitoring matrix

Yunsun Jeong; Sunggyu Lee; Sunmi Kim; Jeongim Park; Hai Joong Kim; Gyuyeon Choi; Sooran Choi; Sungjoo Kim; Su Young Kim; Sungkyoon Kim; Kyungho Choi; Hyo Bang Moon

doi:10.1016/j.scitotenv.2017.07.054

Placental transfer of persistent organic pollutants and feasibility using the placenta as a non-invasive biomonitoring matrix

Yunsun Jeong, Sunggyu Lee, Sunmi Kim, Jeongim Park, Hai Joong Kim, Gyuyeon Choi, Sooran Choi, Sungjoo Kim, Su Young Kim, Sungkyoon Kim, Kyungho Choi, Hyo Bang Moon

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59 Citations (Scopus)

Abstract

The placenta is a crucial organ for the supply of oxygen and nutritional elements from mother to fetus. Several studies have reported evidence of the placental transfer of persistent organic pollutants (POPs). Despite the importance of prenatal exposure to POPs, the transport process of POPs via the human placenta is not well understood. To investigate the transport processes of these contaminants and to assess the feasibility of the placenta as a non-invasive biological matrix, we measured 19 polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs), and 24 polybrominated diphenyl ethers (PBDEs) in placenta tissues. The total concentrations of PCBs, OCPs, and PBDEs in placental tissues ranged from 0.36 to 75.2 (median: 5.85) ng/g lipid wt, 1.37 to 250 (63.5) ng/g lipid wt, and 1.21 to 427 (11.7) ng/g lipid wt, respectively. The BDE 209 concentrations were higher than those reported in previous studies presumably because of the high consumption of deca-BDE technical mixtures in Korea. The concentrations of all of the POPs in placental tissues correlated significantly with each other, but BDE 209 concentration did not correlate with that of any other contaminants possibly because of different exposure sources and kinetics. Maternal age, body mass index, and parity were contributors to the accumulation of several POPs in the placenta. Partitioning ratios between maternal blood–placenta–cord blood showed that lower molecular-weight and hydrophobic POPs were preferentially transported from maternal blood to the placenta and that higher molecular-weight and hydrophobic contaminants tended to remain in placental tissues. Regression analysis showed significant relationships between the POP concentrations in multiple biological matrices such as maternal blood, placenta, cord blood, and meconium. These relationships suggest that the placenta can be used as a non-invasive matrix for biomonitoring prenatal exposure to several POPs.

Original language	English
Pages (from-to)	1498-1505
Number of pages	8
Journal	Science of the Total Environment
Volume	612
DOIs	https://doi.org/10.1016/j.scitotenv.2017.07.054
Publication status	Published - 2018 Jan 15

Bibliographical note

Funding Information:
We would like to express our gratitude to the participating mothers in the Children's Health and Environmental Chemicals in Korea (CHECK) cohort for their great efforts in collecting placenta samples. This study was supported by the Ministry of Environment (MoE) of Korea through the “Integrated Risk Assessment Method for EDCs (IRAMe; 1485014553 )” and “Developing Environmental Hazard and Exposure Assessment Platform for Integrated Risk Management of EDCs in Korea (ecoREA; 1485014467 )” programs.

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

BDE 209
Biomonitoring
POPs
Partitioning
Placental transfer

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Waste Management and Disposal
Pollution

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10.1016/j.scitotenv.2017.07.054

Cite this

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title = "Placental transfer of persistent organic pollutants and feasibility using the placenta as a non-invasive biomonitoring matrix",

abstract = "The placenta is a crucial organ for the supply of oxygen and nutritional elements from mother to fetus. Several studies have reported evidence of the placental transfer of persistent organic pollutants (POPs). Despite the importance of prenatal exposure to POPs, the transport process of POPs via the human placenta is not well understood. To investigate the transport processes of these contaminants and to assess the feasibility of the placenta as a non-invasive biological matrix, we measured 19 polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs), and 24 polybrominated diphenyl ethers (PBDEs) in placenta tissues. The total concentrations of PCBs, OCPs, and PBDEs in placental tissues ranged from 0.36 to 75.2 (median: 5.85) ng/g lipid wt, 1.37 to 250 (63.5) ng/g lipid wt, and 1.21 to 427 (11.7) ng/g lipid wt, respectively. The BDE 209 concentrations were higher than those reported in previous studies presumably because of the high consumption of deca-BDE technical mixtures in Korea. The concentrations of all of the POPs in placental tissues correlated significantly with each other, but BDE 209 concentration did not correlate with that of any other contaminants possibly because of different exposure sources and kinetics. Maternal age, body mass index, and parity were contributors to the accumulation of several POPs in the placenta. Partitioning ratios between maternal blood–placenta–cord blood showed that lower molecular-weight and hydrophobic POPs were preferentially transported from maternal blood to the placenta and that higher molecular-weight and hydrophobic contaminants tended to remain in placental tissues. Regression analysis showed significant relationships between the POP concentrations in multiple biological matrices such as maternal blood, placenta, cord blood, and meconium. These relationships suggest that the placenta can be used as a non-invasive matrix for biomonitoring prenatal exposure to several POPs.",

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author = "Yunsun Jeong and Sunggyu Lee and Sunmi Kim and Jeongim Park and Kim, {Hai Joong} and Gyuyeon Choi and Sooran Choi and Sungjoo Kim and Kim, {Su Young} and Sungkyoon Kim and Kyungho Choi and Moon, {Hyo Bang}",

note = "Funding Information: We would like to express our gratitude to the participating mothers in the Children's Health and Environmental Chemicals in Korea (CHECK) cohort for their great efforts in collecting placenta samples. This study was supported by the Ministry of Environment (MoE) of Korea through the “Integrated Risk Assessment Method for EDCs (IRAMe; 1485014553 )” and “Developing Environmental Hazard and Exposure Assessment Platform for Integrated Risk Management of EDCs in Korea (ecoREA; 1485014467 )” programs. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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AU - Jeong, Yunsun

AU - Lee, Sunggyu

AU - Kim, Sunmi

AU - Park, Jeongim

AU - Kim, Hai Joong

AU - Choi, Gyuyeon

AU - Choi, Sooran

AU - Kim, Sungjoo

AU - Kim, Su Young

AU - Kim, Sungkyoon

AU - Choi, Kyungho

AU - Moon, Hyo Bang

N1 - Funding Information: We would like to express our gratitude to the participating mothers in the Children's Health and Environmental Chemicals in Korea (CHECK) cohort for their great efforts in collecting placenta samples. This study was supported by the Ministry of Environment (MoE) of Korea through the “Integrated Risk Assessment Method for EDCs (IRAMe; 1485014553 )” and “Developing Environmental Hazard and Exposure Assessment Platform for Integrated Risk Management of EDCs in Korea (ecoREA; 1485014467 )” programs. Publisher Copyright: © 2017 Elsevier B.V.

PY - 2018/1/15

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N2 - The placenta is a crucial organ for the supply of oxygen and nutritional elements from mother to fetus. Several studies have reported evidence of the placental transfer of persistent organic pollutants (POPs). Despite the importance of prenatal exposure to POPs, the transport process of POPs via the human placenta is not well understood. To investigate the transport processes of these contaminants and to assess the feasibility of the placenta as a non-invasive biological matrix, we measured 19 polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs), and 24 polybrominated diphenyl ethers (PBDEs) in placenta tissues. The total concentrations of PCBs, OCPs, and PBDEs in placental tissues ranged from 0.36 to 75.2 (median: 5.85) ng/g lipid wt, 1.37 to 250 (63.5) ng/g lipid wt, and 1.21 to 427 (11.7) ng/g lipid wt, respectively. The BDE 209 concentrations were higher than those reported in previous studies presumably because of the high consumption of deca-BDE technical mixtures in Korea. The concentrations of all of the POPs in placental tissues correlated significantly with each other, but BDE 209 concentration did not correlate with that of any other contaminants possibly because of different exposure sources and kinetics. Maternal age, body mass index, and parity were contributors to the accumulation of several POPs in the placenta. Partitioning ratios between maternal blood–placenta–cord blood showed that lower molecular-weight and hydrophobic POPs were preferentially transported from maternal blood to the placenta and that higher molecular-weight and hydrophobic contaminants tended to remain in placental tissues. Regression analysis showed significant relationships between the POP concentrations in multiple biological matrices such as maternal blood, placenta, cord blood, and meconium. These relationships suggest that the placenta can be used as a non-invasive matrix for biomonitoring prenatal exposure to several POPs.

AB - The placenta is a crucial organ for the supply of oxygen and nutritional elements from mother to fetus. Several studies have reported evidence of the placental transfer of persistent organic pollutants (POPs). Despite the importance of prenatal exposure to POPs, the transport process of POPs via the human placenta is not well understood. To investigate the transport processes of these contaminants and to assess the feasibility of the placenta as a non-invasive biological matrix, we measured 19 polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs), and 24 polybrominated diphenyl ethers (PBDEs) in placenta tissues. The total concentrations of PCBs, OCPs, and PBDEs in placental tissues ranged from 0.36 to 75.2 (median: 5.85) ng/g lipid wt, 1.37 to 250 (63.5) ng/g lipid wt, and 1.21 to 427 (11.7) ng/g lipid wt, respectively. The BDE 209 concentrations were higher than those reported in previous studies presumably because of the high consumption of deca-BDE technical mixtures in Korea. The concentrations of all of the POPs in placental tissues correlated significantly with each other, but BDE 209 concentration did not correlate with that of any other contaminants possibly because of different exposure sources and kinetics. Maternal age, body mass index, and parity were contributors to the accumulation of several POPs in the placenta. Partitioning ratios between maternal blood–placenta–cord blood showed that lower molecular-weight and hydrophobic POPs were preferentially transported from maternal blood to the placenta and that higher molecular-weight and hydrophobic contaminants tended to remain in placental tissues. Regression analysis showed significant relationships between the POP concentrations in multiple biological matrices such as maternal blood, placenta, cord blood, and meconium. These relationships suggest that the placenta can be used as a non-invasive matrix for biomonitoring prenatal exposure to several POPs.

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Placental transfer of persistent organic pollutants and feasibility using the placenta as a non-invasive biomonitoring matrix

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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