TY - JOUR
T1 - Placental transfer of persistent organic pollutants and feasibility using the placenta as a non-invasive biomonitoring matrix
AU - Jeong, Yunsun
AU - Lee, Sunggyu
AU - Kim, Sunmi
AU - Park, Jeongim
AU - Kim, Hai Joong
AU - Choi, Gyuyeon
AU - Choi, Sooran
AU - Kim, Sungjoo
AU - Kim, Su Young
AU - Kim, Sungkyoon
AU - Choi, Kyungho
AU - Moon, Hyo Bang
N1 - Funding Information:
We would like to express our gratitude to the participating mothers in the Children's Health and Environmental Chemicals in Korea (CHECK) cohort for their great efforts in collecting placenta samples. This study was supported by the Ministry of Environment (MoE) of Korea through the “Integrated Risk Assessment Method for EDCs (IRAMe; 1485014553 )” and “Developing Environmental Hazard and Exposure Assessment Platform for Integrated Risk Management of EDCs in Korea (ecoREA; 1485014467 )” programs.
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/1/15
Y1 - 2018/1/15
N2 - The placenta is a crucial organ for the supply of oxygen and nutritional elements from mother to fetus. Several studies have reported evidence of the placental transfer of persistent organic pollutants (POPs). Despite the importance of prenatal exposure to POPs, the transport process of POPs via the human placenta is not well understood. To investigate the transport processes of these contaminants and to assess the feasibility of the placenta as a non-invasive biological matrix, we measured 19 polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs), and 24 polybrominated diphenyl ethers (PBDEs) in placenta tissues. The total concentrations of PCBs, OCPs, and PBDEs in placental tissues ranged from 0.36 to 75.2 (median: 5.85) ng/g lipid wt, 1.37 to 250 (63.5) ng/g lipid wt, and 1.21 to 427 (11.7) ng/g lipid wt, respectively. The BDE 209 concentrations were higher than those reported in previous studies presumably because of the high consumption of deca-BDE technical mixtures in Korea. The concentrations of all of the POPs in placental tissues correlated significantly with each other, but BDE 209 concentration did not correlate with that of any other contaminants possibly because of different exposure sources and kinetics. Maternal age, body mass index, and parity were contributors to the accumulation of several POPs in the placenta. Partitioning ratios between maternal blood–placenta–cord blood showed that lower molecular-weight and hydrophobic POPs were preferentially transported from maternal blood to the placenta and that higher molecular-weight and hydrophobic contaminants tended to remain in placental tissues. Regression analysis showed significant relationships between the POP concentrations in multiple biological matrices such as maternal blood, placenta, cord blood, and meconium. These relationships suggest that the placenta can be used as a non-invasive matrix for biomonitoring prenatal exposure to several POPs.
AB - The placenta is a crucial organ for the supply of oxygen and nutritional elements from mother to fetus. Several studies have reported evidence of the placental transfer of persistent organic pollutants (POPs). Despite the importance of prenatal exposure to POPs, the transport process of POPs via the human placenta is not well understood. To investigate the transport processes of these contaminants and to assess the feasibility of the placenta as a non-invasive biological matrix, we measured 19 polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs), and 24 polybrominated diphenyl ethers (PBDEs) in placenta tissues. The total concentrations of PCBs, OCPs, and PBDEs in placental tissues ranged from 0.36 to 75.2 (median: 5.85) ng/g lipid wt, 1.37 to 250 (63.5) ng/g lipid wt, and 1.21 to 427 (11.7) ng/g lipid wt, respectively. The BDE 209 concentrations were higher than those reported in previous studies presumably because of the high consumption of deca-BDE technical mixtures in Korea. The concentrations of all of the POPs in placental tissues correlated significantly with each other, but BDE 209 concentration did not correlate with that of any other contaminants possibly because of different exposure sources and kinetics. Maternal age, body mass index, and parity were contributors to the accumulation of several POPs in the placenta. Partitioning ratios between maternal blood–placenta–cord blood showed that lower molecular-weight and hydrophobic POPs were preferentially transported from maternal blood to the placenta and that higher molecular-weight and hydrophobic contaminants tended to remain in placental tissues. Regression analysis showed significant relationships between the POP concentrations in multiple biological matrices such as maternal blood, placenta, cord blood, and meconium. These relationships suggest that the placenta can be used as a non-invasive matrix for biomonitoring prenatal exposure to several POPs.
KW - BDE 209
KW - Biomonitoring
KW - POPs
KW - Partitioning
KW - Placental transfer
UR - http://www.scopus.com/inward/record.url?scp=85029181323&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2017.07.054
DO - 10.1016/j.scitotenv.2017.07.054
M3 - Article
C2 - 28910963
AN - SCOPUS:85029181323
SN - 0048-9697
VL - 612
SP - 1498
EP - 1505
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -