Plasma adiponectin is associated with less atherogenic lipoprotein phenotype

M. J. Shin, O. Y. Kim

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background and aims: This study examined the relationships between plasma levels of adiponectin and the features of the atherogenic lipoprotein phenotype (ALP), including HDL subclasses. Methods and results: Blood lipids and apolipoproteins were measured in 293 healthy individuals. LDL particle size and HDL subspecies (HDL 2, HDL 3) were measured using gradient gel electrophoresis. Plasma adiponectin levels were negatively correlated with levels of apoB (r=-0.199, p<0.001), TG (r=-0.262, p<0.001), and HOMA-IR (r=-0.323, p<0.001) and positively correlated with levels of apoAI (r=0.173, p=0.006), HDL-cholesterol (r=0.287, p<0.001), and LDL particle size (r=0.289, p<0.001). Multiple linear regression analysis revealed the relationship between plasma adiponectin and LDL particle size (p<0.05) was no longer significant after adjusting for plasma TG levels. However, adiponectin (p<0.005) together with apoAI and TG were independent factors for HDL-cholesterol. With regard to HDL subclasses, plasma adiponectin levels were positively correlated with HDL 2b (r=0.204, p<0.001), HDL 2a (r=0.132, p<0.05) and negatively with HDL 3a (r=-0.128, p<0.05), HDL 3b (r=-0.203, p<0.001), and HDL 3c (r=-0.159, p<0.01). The relationship between circulating adiponectin and HDL 2 (HDL 2b+HDL 2a) was independent of apoB and TG levels (p<0.05), but not of apoAI and HOMA-IR. Conclusions: Our results show that circulating adiponectin is associated with reduced manifestations of ALP.

Original languageEnglish
Pages (from-to)770-775
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number10
Publication statusPublished - 2011 Oct


  • Adiponectin
  • Atherogenic lipoprotein phenotype
  • HDL subclass
  • Insulin resistance
  • LDL particle size

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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