TY - JOUR
T1 - Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer
AU - Jeong, Nan Hee
AU - Song, Eun Seop
AU - Lee, Jong Min
AU - Lee, Kwang Beom
AU - Kim, Mi Kyung
AU - Cheon, Ji Eun
AU - Lee, Jae Kwan
AU - Son, Sung Kyong
AU - Lee, Jung Pil
AU - Kim, Jae Hoon
AU - Hur, Soo Young
AU - Kwon, Yong Il
PY - 2009
Y1 - 2009
N2 - Objective. We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Six tertiary medical institutes in Korea. Population. Forty-five epithelial ovarian cancers and 135 age-matched controls. Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Main outcome measures. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. Results. Women in the highest tertile for -carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), -tocopherol (OR 0.23; 95%CI 0.10-0.53) and -tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. Conclusions. Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, -tocopherol, and -tocopherol, may play a role in reducing the risk of ovarian cancer.
AB - Objective. We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Six tertiary medical institutes in Korea. Population. Forty-five epithelial ovarian cancers and 135 age-matched controls. Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Main outcome measures. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. Results. Women in the highest tertile for -carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), -tocopherol (OR 0.23; 95%CI 0.10-0.53) and -tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. Conclusions. Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, -tocopherol, and -tocopherol, may play a role in reducing the risk of ovarian cancer.
KW - Carotenoids
KW - ovarian cancer
KW - tocopherol
KW - vitamin A
UR - http://www.scopus.com/inward/record.url?scp=64849095810&partnerID=8YFLogxK
U2 - 10.1080/00016340902807215
DO - 10.1080/00016340902807215
M3 - Article
C2 - 19266359
AN - SCOPUS:64849095810
SN - 0001-6349
VL - 88
SP - 457
EP - 462
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
IS - 4
ER -
