Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment

Soo Lee Kang; Hyung Chung Ji; Hye Lee Kyung; Min Jeong Shin; Hoon Oh Byoung; Hyung Lee Soo; Hyung Hong Chang

doi:10.1038/cmi.2009.20

Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment

Soo Lee Kang, Hyung Chung Ji, Hye Lee Kyung, Min Jeong Shin, Hoon Oh Byoung, Hyung Lee Soo, Hyung Hong Chang

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

Original language	English
Pages (from-to)	143-147
Number of pages	5
Journal	Cellular and Molecular Immunology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1038/cmi.2009.20
Publication status	Published - 2009 Apr

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health 21 R&D Project of the Ministry of Health & Welfare, Republic of Korea (A050079).

Keywords

Biomarker
Cytokine
Inflammation
Mild cognitive impairment
Plasma

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/cmi.2009.20

Cite this

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title = "Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment",

abstract = "A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.",

keywords = "Biomarker, Cytokine, Inflammation, Mild cognitive impairment, Plasma",

author = "Kang, {Soo Lee} and Ji, {Hyung Chung} and Kyung, {Hye Lee} and Shin, {Min Jeong} and Byoung, {Hoon Oh} and Soo, {Hyung Lee} and Chang, {Hyung Hong}",

note = "Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project of the Ministry of Health & Welfare, Republic of Korea (A050079).",

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doi = "10.1038/cmi.2009.20",

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AU - Kang, Soo Lee

AU - Ji, Hyung Chung

AU - Kyung, Hye Lee

AU - Shin, Min Jeong

AU - Byoung, Hoon Oh

AU - Soo, Hyung Lee

AU - Chang, Hyung Hong

N1 - Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project of the Ministry of Health & Welfare, Republic of Korea (A050079).

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AB - A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

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KW - Cytokine

KW - Inflammation

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KW - Plasma

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Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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