Platelet and bacterial repellence on sulfonated poly(ethylene glycol)-acrylate copolymer surfaces

Hee Jung Lee; Ki Dong Park; Hyung Dal Park; Won Kyu Lee; Dong Keun Han; Soo Hyun Kim; Young Ha Kim

doi:10.1016/S0927-7765(99)00161-7

Platelet and bacterial repellence on sulfonated poly(ethylene glycol)-acrylate copolymer surfaces

Hee Jung Lee, Ki Dong Park, Hyung Dal Park, Won Kyu Lee, Dong Keun Han, Soo Hyun Kim, Young Ha Kim

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Novel poly(ethylene glycol) (PEG) and sulfonated PEG (PEG-SO₃) acrylate copolymers have been prepared and characterized to apply as coating and blending materials for biomedical applications. The modified surfaces using acrylate copolymers demonstrated increased hydrophilicity, possibly due to the hypothesized reorientation of PEG/PEG-SO₃ chains into water phase. All copolymer surfaces demonstrated less platelet adhesion than control. In addition, platelet adhesion on copolymer surfaces decreased as the chain length of PEG and sulfonated PEG in copolymers increases. All copolymer surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. The obtained results attest to the usefulness of these copolymers as a coating or additive material to improve the blood compatibility of blood contacting devices.

Original language	English
Pages (from-to)	355-370
Number of pages	16
Journal	Colloids and Surfaces B: Biointerfaces
Volume	18
Issue number	3-4
DOIs	https://doi.org/10.1016/S0927-7765(99)00161-7
Publication status	Published - 2000 Oct

Keywords

Bacterial adhesion
Platelet adhesion
Sulfonated-PEG acrylate copolymers

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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10.1016/S0927-7765(99)00161-7

Cite this

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title = "Platelet and bacterial repellence on sulfonated poly(ethylene glycol)-acrylate copolymer surfaces",

abstract = "Novel poly(ethylene glycol) (PEG) and sulfonated PEG (PEG-SO3) acrylate copolymers have been prepared and characterized to apply as coating and blending materials for biomedical applications. The modified surfaces using acrylate copolymers demonstrated increased hydrophilicity, possibly due to the hypothesized reorientation of PEG/PEG-SO3 chains into water phase. All copolymer surfaces demonstrated less platelet adhesion than control. In addition, platelet adhesion on copolymer surfaces decreased as the chain length of PEG and sulfonated PEG in copolymers increases. All copolymer surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. The obtained results attest to the usefulness of these copolymers as a coating or additive material to improve the blood compatibility of blood contacting devices.",

keywords = "Bacterial adhesion, Platelet adhesion, Sulfonated-PEG acrylate copolymers",

author = "Lee, {Hee Jung} and Park, {Ki Dong} and Park, {Hyung Dal} and Lee, {Won Kyu} and Han, {Dong Keun} and Kim, {Soo Hyun} and Kim, {Young Ha}",

note = "Funding Information: This study was supported by a grant (HMP-98-G-2-041) of the HAN Project, Ministry of Health and Welfare, R.O.K. ",

year = "2000",

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doi = "10.1016/S0927-7765(99)00161-7",

language = "English",

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pages = "355--370",

journal = "Colloids and Surfaces B: Biointerfaces",

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TY - JOUR

T1 - Platelet and bacterial repellence on sulfonated poly(ethylene glycol)-acrylate copolymer surfaces

AU - Lee, Hee Jung

AU - Park, Ki Dong

AU - Park, Hyung Dal

AU - Lee, Won Kyu

AU - Han, Dong Keun

AU - Kim, Soo Hyun

AU - Kim, Young Ha

N1 - Funding Information: This study was supported by a grant (HMP-98-G-2-041) of the HAN Project, Ministry of Health and Welfare, R.O.K.

PY - 2000/10

Y1 - 2000/10

N2 - Novel poly(ethylene glycol) (PEG) and sulfonated PEG (PEG-SO3) acrylate copolymers have been prepared and characterized to apply as coating and blending materials for biomedical applications. The modified surfaces using acrylate copolymers demonstrated increased hydrophilicity, possibly due to the hypothesized reorientation of PEG/PEG-SO3 chains into water phase. All copolymer surfaces demonstrated less platelet adhesion than control. In addition, platelet adhesion on copolymer surfaces decreased as the chain length of PEG and sulfonated PEG in copolymers increases. All copolymer surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. The obtained results attest to the usefulness of these copolymers as a coating or additive material to improve the blood compatibility of blood contacting devices.

AB - Novel poly(ethylene glycol) (PEG) and sulfonated PEG (PEG-SO3) acrylate copolymers have been prepared and characterized to apply as coating and blending materials for biomedical applications. The modified surfaces using acrylate copolymers demonstrated increased hydrophilicity, possibly due to the hypothesized reorientation of PEG/PEG-SO3 chains into water phase. All copolymer surfaces demonstrated less platelet adhesion than control. In addition, platelet adhesion on copolymer surfaces decreased as the chain length of PEG and sulfonated PEG in copolymers increases. All copolymer surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. The obtained results attest to the usefulness of these copolymers as a coating or additive material to improve the blood compatibility of blood contacting devices.

KW - Bacterial adhesion

KW - Platelet adhesion

KW - Sulfonated-PEG acrylate copolymers

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U2 - 10.1016/S0927-7765(99)00161-7

DO - 10.1016/S0927-7765(99)00161-7

M3 - Article

AN - SCOPUS:0033939873

SN - 0927-7765

VL - 18

SP - 355

EP - 370

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 3-4

ER -

Platelet and bacterial repellence on sulfonated poly(ethylene glycol)-acrylate copolymer surfaces

Abstract

Keywords

ASJC Scopus subject areas

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